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This meeting took place in 2009
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Pattern Recognition Molecules and Immune Sensors of Pathogens (Z1)
Organizer(s) Jenny P. Ting, Richard A. Flavell and Luke A.J. O'Neill
March 29—April 3, 2009
Fairmont Banff Springs • Banff, Alberta Canada
Abstract Deadline: Dec 2, 2008
Late Abstract Deadline: Dec 31, 2008
Scholarship Deadline: Dec 2, 2008
Early Registration Deadline: Jan 29, 2009
Supported by the Directors' Fund
Joint Meeting:
Dendritic Cells (Z2)
Summary of Meeting:
The discovery of evolutionarily conserved immune genes and pathways has led to an explosive discovery phase in innate immunity. These pathways include TLR, NLR, C-type lectin Receptor, and the helicase-containing anti-viral proteins. These novel pathways merge the innate and adaptive branches of immunity, and converge on a wide range of disorders including infectious diseases, inflammation and autoimmunity. All of the above have systemic effects that can affect the outcome of a wide range of diseases ranging from cancer to cardiovascular disorders.
View Scholarships/Awards
The discovery of evolutionarily conserved immune genes and pathways has led to an explosive discovery phase in innate immunity. These pathways include TLR, NLR, C-type lectin Receptor, and the helicase-containing anti-viral proteins. These novel pathways merge the innate and adaptive branches of immunity, and converge on a wide range of disorders including infectious diseases, inflammation and autoimmunity. All of the above have systemic effects that can affect the outcome of a wide range of diseases ranging from cancer to cardiovascular disorders.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, MARCH 29
MONDAY, MARCH 30
TUESDAY, MARCH 31
WEDNESDAY, APRIL 1
THURSDAY, APRIL 2
FRIDAY, APRIL 3
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, MARCH 29
19:30—21:30
Keynote Session (Joint)
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Jenny P.Y. Ting,
University of North Carolina at Chapel Hill, USA
Ira Mellman,
Genentech, Inc., USA
Cell Biology of Antigen Processing by Dendritic Cells
Cell Biology of Antigen Processing by Dendritic Cells
08:00—11:15
TLRs - I
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Bruce A. Beutler,
University of Texas Southwestern Medical Center, USA
Mutagenesis in the Analysis of Pathogen Sensing Pathways
Mutagenesis in the Analysis of Pathogen Sensing Pathways
Luke A. J. O'Neill,
Trinity Biomedical Sciences Institute, Ireland
The IL-1 Receptor / Toll-Like Receptor Superfamily: 10 Years of Progress
The IL-1 Receptor / Toll-Like Receptor Superfamily: 10 Years of Progress
Ruslan Medzhitov,
HHMI/Yale University School of Medicine, USA
A Mechanism of an Allergen-Induced Immune Response
A Mechanism of an Allergen-Induced Immune Response
Sarah Ewald,
Stanford University, USA
Short Talk: The Ectodomain of Toll-like Receptor 9 is Cleaved to Generate a Functional Receptor
Short Talk: The Ectodomain of Toll-like Receptor 9 is Cleaved to Generate a Functional Receptor
Markus G. Manz,
University Hospital Zürich, Switzerland
Short Talk: Human Bone Marrow Multipotent Mesenchymal Stromal Cells Sense TLR4-Agonists and Subsequently Enhance Myelopoiesis
Short Talk: Human Bone Marrow Multipotent Mesenchymal Stromal Cells Sense TLR4-Agonists and Subsequently Enhance Myelopoiesis
Stephanie C. Eisenbarth,
Yale University, USA
Short Talk: Activation of Adaptive Immunity but not Th2 Differentiation by the Nalp3 Inflammasome
Short Talk: Activation of Adaptive Immunity but not Th2 Differentiation by the Nalp3 Inflammasome
08:00—11:30
Phagocytosis and Antigen Presentation
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Ira Mellman,
Genentech, Inc., USA
Sebastian Amigorena,
Institut Curie, France
A New Soluble Ligand of DCSign Present in Human Semen Inhibits HIV Trans-Infection of T Cells
A New Soluble Ligand of DCSign Present in Human Semen Inhibits HIV Trans-Infection of T Cells
David G. Russell,
Cornell University, USA
Reprogramming Phagosomal Function in Macrophages and Dendritic Cells
Reprogramming Phagosomal Function in Macrophages and Dendritic Cells
Jose A. Villadangos,
University of Melbourne, Australia
Antigen Presentation Specializations in the Dendritic Cell Network
Antigen Presentation Specializations in the Dendritic Cell Network
Romina S. Goldszmid,
NCI, National Institutes of Health, USA
Short Talk: Host ER-Parasitophorous Vacuole Interaction Provides a Route of Entry for Antigen Cross-Presentation in Toxoplasma Infected Dendritic Cells
Short Talk: Host ER-Parasitophorous Vacuole Interaction Provides a Route of Entry for Antigen Cross-Presentation in Toxoplasma Infected Dendritic Cells
Bali Pulendran,
Stanford University School of Medicine, USA
Modulating Vaccine Responses with Innate Immunity
Modulating Vaccine Responses with Innate Immunity
14:30—16:30
Workshop 1: TLR and Other Pathogen Sensors
Michael Carty,
Trinity College Dublin, Ireland
Regulation of TRIF- dependent TLR Signaling by the Adaptor SARM
Regulation of TRIF- dependent TLR Signaling by the Adaptor SARM
Ping Zhang,
University of Alabama, Birmingham, USA
TLR2-dependent Modulation of Osteoclastogenesis by Porphyromonas gingivalis
TLR2-dependent Modulation of Osteoclastogenesis by Porphyromonas gingivalis
Brendan J. Jenkins,
Hudson Institute of Medical Research, Australia
Interplay between the Interleukin-6 Cytokine Family and Toll-like Receptors in Inflammation and Gastric Tumorigenesis
Interplay between the Interleukin-6 Cytokine Family and Toll-like Receptors in Inflammation and Gastric Tumorigenesis
Jaime Pascual,
Sanford-Burnham Medical Research Institute, USA
Molecular Mimicry in Innate Immunity: Crystal Structure of a Bacteria TIR Virulence Factor
Molecular Mimicry in Innate Immunity: Crystal Structure of a Bacteria TIR Virulence Factor
Kathryn J. Moore,
New York University Medical Center, USA
CD36 Ligands Promote Sterile Inflammation through Assembly of a TLR 4 and 6 Heterodimer
CD36 Ligands Promote Sterile Inflammation through Assembly of a TLR 4 and 6 Heterodimer
Emily L. Lowe,
University of California, Los Angeles, USA
TLR2 is Protective in Colitis-associated Colorectal Cancer
TLR2 is Protective in Colitis-associated Colorectal Cancer
Yue Guan,
University of Illinois at Urbana-Champaign, USA
Human Toll-like Receptors 10 and 1 Share Common Mechanisms of Innate Immune Sensing but not Signaling
Human Toll-like Receptors 10 and 1 Share Common Mechanisms of Innate Immune Sensing but not Signaling
Anca Dorhoi,
Friedrich-Loeffler-Institut, Germany
The Adaptor Protein CARD9 is Essential for Tuberculosis Control
The Adaptor Protein CARD9 is Essential for Tuberculosis Control
14:30—16:30
Workshop 1: Antigen Presentation and T Cell Activation
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Sebastian Amigorena,
Institut Curie, France
Sofia Bogiatzi,
Institut Curie, France
Reciprocal Inhibition of the TSLP and Th17 Immune Pathways
Reciprocal Inhibition of the TSLP and Th17 Immune Pathways
Anuradha Ray,
University of Pittsburgh School of Medicine, USA
Dual c-kit-Stem Cell Factor Upregulation by Allergens in Dendritic Cells Promotes IL-6 but Limits IL-12 Impacting T Helper Cell Differentiation and Allergic Asthma
Dual c-kit-Stem Cell Factor Upregulation by Allergens in Dendritic Cells Promotes IL-6 but Limits IL-12 Impacting T Helper Cell Differentiation and Allergic Asthma
Thomas Duhen,
Agonox, USA
Identification and Characterization of IL-22-Only Producing CD4+ T Cells: Role of Plasmacytoid DC for their Differentiation
Identification and Characterization of IL-22-Only Producing CD4+ T Cells: Role of Plasmacytoid DC for their Differentiation
Guillaume Hoeffel,
Singapore Immunology Network, Singapore
HIV Antigen Crosspresentation Pathways from Apoptotic, Infected CD4+ T Cells, in Plasmacytoid Dendritic Cell
HIV Antigen Crosspresentation Pathways from Apoptotic, Infected CD4+ T Cells, in Plasmacytoid Dendritic Cell
Roger V. Belizaire,
Washington University in St. Louis, USA
Exogenous Antigen Enters the Major Histocompatibility Complex (MHC) Class I Processing and Presentation Pathway via Multiple Endocytic Compartments with Distinct Molecular and Proteolytic Requirements
Exogenous Antigen Enters the Major Histocompatibility Complex (MHC) Class I Processing and Presentation Pathway via Multiple Endocytic Compartments with Distinct Molecular and Proteolytic Requirements
Roberto A. Maldonado,
Selecta Biosciences, USA
Rapamycin- and TGFbeta-Treated Dendritic Cells Induce Tolerance and de novo Differentiation of Regulatory T Cells in vitro and in vivo
Rapamycin- and TGFbeta-Treated Dendritic Cells Induce Tolerance and de novo Differentiation of Regulatory T Cells in vitro and in vivo
Mireille H. Lahoud,
Burnet Institute, Australia
Clec9A on the Surface of Dendritic Cells is a Dead Cell Recognition Molecule
Clec9A on the Surface of Dendritic Cells is a Dead Cell Recognition Molecule
David Sancho,
CNIC-Fundación Centro Nacional de Investigaciones Cardiovasculares, Spain
Identification of a Dendritic Cell Receptor that Couples Sensing of Necrosis to Immunity
Identification of a Dendritic Cell Receptor that Couples Sensing of Necrosis to Immunity
17:00—19:00
TLRs - II
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Luke A. J. O'Neill,
Trinity Biomedical Sciences Institute, Ireland
Siamon Gordon,
Chang Gung University / University of Oxford, UK
Regulation of Macrophage Function by Surface Receptors and TH2 Cytokines
Regulation of Macrophage Function by Surface Receptors and TH2 Cytokines
Ann Marshak-Rothstein,
University of Massachusetts Medical School, USA
BCR, TLR and IFNaR Regulation of Autoreactive B Cells
BCR, TLR and IFNaR Regulation of Autoreactive B Cells
Arthur M. Krieg,
Checkmate Pharmaceuticals, USA
Therapeutic Usage of Nucleic Acid TLR Agonists
Therapeutic Usage of Nucleic Acid TLR Agonists
Wajahat Z. Mehal,
Yale University, USA
Short Talk: Acetaminophen Induced Hepatotoxicity is Dependent on TLR7/9 and the NALP3 Inflammasome
Short Talk: Acetaminophen Induced Hepatotoxicity is Dependent on TLR7/9 and the NALP3 Inflammasome
17:00—19:00
DCs in Tolerance, Immunity, and T Cell Differentiation
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Daniel J. Cua,
Merck Research Laboratories, USA
The IL-23/IL-17 Axis
The IL-23/IL-17 Axis
Yong-Jun Liu,
Sanofi, USA
Thymic Stromal Lymphopoietin Program Dendritic Cells to Induce TH2 Inflammation through a Unique Set of Signal Codes
Thymic Stromal Lymphopoietin Program Dendritic Cells to Induce TH2 Inflammation through a Unique Set of Signal Codes
Erica L. Granger,
Pennsylvania State College of Medicine, USA
Short Talk: Persistence of MHC Class I-Restricted Antigen Presentation Following Acute Virus Infection Requires Direct and then Cross Presentation
Short Talk: Persistence of MHC Class I-Restricted Antigen Presentation Following Acute Virus Infection Requires Direct and then Cross Presentation
Vijay K. Kuchroo,
Brigham and Women's Hospital, Harvard Medical School, USA
Tim-3 and Expansion of Regulatory Antigen Presenting Cells
Tim-3 and Expansion of Regulatory Antigen Presenting Cells
08:00—11:15
NLR/NBD-LRR Proteins, Pathways and Diseases
Meeting has ended...abstracts no longer viewable online.
Jonathan D.G. Jones,
Sainsbury Laboratory, UK
Using Pathogen Effectors to Understand Host Resistance Mechanisms
Using Pathogen Effectors to Understand Host Resistance Mechanisms
Jenny P.Y. Ting,
University of North Carolina at Chapel Hill, USA
NLR in Diseases and Health
NLR in Diseases and Health
John C. Reed,
F. Hoffmann-La Roche AG, Switzerland
Linking Innate Immunity with the Cell Death Machinery: Interactions of NLR and Bcl-2 Family Proteins
Linking Innate Immunity with the Cell Death Machinery: Interactions of NLR and Bcl-2 Family Proteins
Tara L. Roberts,
Queensland Institute of Medical Research, Australia
Short Talk: The Role of HIN200 Family Proteins in the Response to Cytosolic DNA
Short Talk: The Role of HIN200 Family Proteins in the Response to Cytosolic DNA
T. Sam Xiao,
Case Western Reserve University, USA
Short Talk: The Structure of NALP1/NLRP1 Leucine-rich Repeats Illustrates a Potential Ligand-binding Site
Short Talk: The Structure of NALP1/NLRP1 Leucine-rich Repeats Illustrates a Potential Ligand-binding Site
08:00—11:15
Dendritic Cell Precursors
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Gwendalyn J. Randolph,
Washington University, USA
Carlos Ardavin,
National Center for Biotechnology, Spain
Monocyte-Derived Dendritic Cells
Monocyte-Derived Dendritic Cells
Steffen Jung,
Weizmann Institute of Science, Israel
Probing Origins and in vivo Functions of Dendritic Cells
Probing Origins and in vivo Functions of Dendritic Cells
Markus G. Manz,
University Hospital Zürich, Switzerland
Lymphoid-Organ Dendritic Cell Homeostasis in Steady-State and Inflammation
Lymphoid-Organ Dendritic Cell Homeostasis in Steady-State and Inflammation
Kang Liu,
Columbia University Medical Center, USA
Short Talk: Dendritic Cell Development and Homeostasis in vivo
Short Talk: Dendritic Cell Development and Homeostasis in vivo
Boris Reizis,
New York University Langone Medical Center, USA
Plasmacytoid Dendritic Cell Differentiation
Plasmacytoid Dendritic Cell Differentiation
Florent Ginhoux,
Singapore Immunology Network, Singapore
Short Talk: Flt3 and Id2-Dependent CD103+ DCs in Non-Lymphoid Tissues Form a Specific DC Lineage Related to Lymphoid CD8+ DCs
Short Talk: Flt3 and Id2-Dependent CD103+ DCs in Non-Lymphoid Tissues Form a Specific DC Lineage Related to Lymphoid CD8+ DCs
17:00—19:00
NLR/NBD-LRR Proteins, Pathways and Diseases - II
Meeting has ended...abstracts no longer viewable online.
Jürg Tschopp,
University of Lausanne, Switzerland
Malarial Hemozoin is a Nalp3 Inflammasome Activating Danger Signal
Malarial Hemozoin is a Nalp3 Inflammasome Activating Danger Signal
Gabriel Nuñez,
University of Michigan, USA
Function of Nod-Like Receptors in Innate Immunity
Function of Nod-Like Receptors in Innate Immunity
Dana Philpott,
University of Toronto, Canada
Nod Proteins and the Interaction of Innate and Adaptive Immunity
Nod Proteins and the Interaction of Innate and Adaptive Immunity
Koichi S. Kobayashi,
Texas A&M Health Science Center, USA
Short Talk: The Role of Nod2-Rip2 Signaling Pathway in the Regulation of Commensal Microbiota in the Intestine
Short Talk: The Role of Nod2-Rip2 Signaling Pathway in the Regulation of Commensal Microbiota in the Intestine
17:00—19:00
Recent Advances
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Dominique Kaiserlian,
INSERM-U851, France
Role of Liver Plasmacytoid DC in Oral Tolerance
Role of Liver Plasmacytoid DC in Oral Tolerance
Yvette van Kooyk,
Vrije University Medical Center, Netherlands
Targeting of DC by Glycosylated Antigens
Targeting of DC by Glycosylated Antigens
Ana-Maria Lennon-Duménil,
Curie Institute, France
Coordinated Regulation of Antigen Presentation and Dendritic Cell Migration
Coordinated Regulation of Antigen Presentation and Dendritic Cell Migration
08:00—11:15
Viral Sensors
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Takashi Fujita,
Institute for Virus Research, Kyoto University, Japan
Solution Structures of MDA5 and LGP2 C-Terminal Domains: Identification of the RNA Recognition Loop in RIG-I Like Receptors
Solution Structures of MDA5 and LGP2 C-Terminal Domains: Identification of the RNA Recognition Loop in RIG-I Like Receptors
Hong-Bing Shu,
Wuhan University, China
Virus-Triggered Signaling Pathways
Virus-Triggered Signaling Pathways
Kate A. Fitzgerald,
University of Massachusetts Medical School, USA
Molecular Mechanisms of DNA Sensing
Molecular Mechanisms of DNA Sensing
Stephanie J. DeWitte-Orr,
McMaster University, Canada
Short Talk: Scavenger Class A-Like Receptor (SLR): A Pathogen Recognition Receptor Mediating DsRNA-Induced Antiviral Responses
Short Talk: Scavenger Class A-Like Receptor (SLR): A Pathogen Recognition Receptor Mediating DsRNA-Induced Antiviral Responses
Axel Kirchhofer,
Gene Center, Germany
Short Talk: Structural and Functional Analysis of RIG-I Like Helicases
Short Talk: Structural and Functional Analysis of RIG-I Like Helicases
08:00—11:15
Dendritic Cells in Disease
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Yong-Jun Liu,
Sanofi, USA
Miriam Merad,
Mount Sinai School of Medicine, USA
Origin of Dendritic Cell Diversity Controls Tissue Immunity
Origin of Dendritic Cell Diversity Controls Tissue Immunity
Gwendalyn J. Randolph,
Washington University, USA
Monocytes, Dendritic Cells, and their Migration in Atherosclerosis
Monocytes, Dendritic Cells, and their Migration in Atherosclerosis
Jerry Aldridge,
St. Jude Children's Research Hospital, USA
Short Talk: tipDCs — The Necessary Evil of Lethal Influenza Infection
Short Talk: tipDCs — The Necessary Evil of Lethal Influenza Infection
Giorgio Trinchieri,
NCI, National Institutes of Health, USA
TLR Signaling in DC: Lessons from Fibroblasts
TLR Signaling in DC: Lessons from Fibroblasts
Vanja Sisirak,
Columbia University, USA
Short Talk: Breast Tumor Environment Alters Human Plasmacytoid Dendritic Cells Functions
Short Talk: Breast Tumor Environment Alters Human Plasmacytoid Dendritic Cells Functions
14:30—16:30
Workshop 2: NLR and Other Pathogen Sensors
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Gordon D. Brown,
University of Aberdeen, UK
Olaf Groß,
Universitätsklinikum Freiburg, Germany
Adjuvanticity of the Synthetic Cord Factor Analog TDB for subunit M. tuberculosis Vaccination Requires Card9-dependent Innate Immune Activation
Adjuvanticity of the Synthetic Cord Factor Analog TDB for subunit M. tuberculosis Vaccination Requires Card9-dependent Innate Immune Activation
Tilmann Bürckstümmer,
Haplogen Genomics, Austria
An Orthogonal Proteomic/Genomic Screen Identifies DSIRE as Cytoplasmic DNA Sensor for the Inflammasome
An Orthogonal Proteomic/Genomic Screen Identifies DSIRE as Cytoplasmic DNA Sensor for the Inflammasome
Paul G. Thomas,
St. Jude Children's Research Hospital, USA
NLRP3 (NALP3/CIAS1/Cryopyrin) Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1
NLRP3 (NALP3/CIAS1/Cryopyrin) Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1
Joseph A. Duncan,
University of North Carolina, Chapel Hill, USA
Staphylococcus aureus a-hemolysin Induces IL-1B Production and Inflammatory Cell Death through Activation of Host NLRP3
Staphylococcus aureus a-hemolysin Induces IL-1B Production and Inflammatory Cell Death through Activation of Host NLRP3
Monique Willart,
Ghent University, Belgium
Edward A. Miao,
University of North Carolina at Chapel Hill, USA
NLRC4 is an Innate Immune Detector of the Bacterial Type III Secretion Apparatus
NLRC4 is an Innate Immune Detector of the Bacterial Type III Secretion Apparatus
Takeshi Ichinohe,
Yale University School of Medicine, USA
Inflammasome Recognition of Influenza Virus is Essential for Adaptive Immune Responses
Inflammasome Recognition of Influenza Virus is Essential for Adaptive Immune Responses
Fengyi Wan,
Johns Hopkins Bloomberg School of Public Health, USA
Ribosomal Protein S3: A Novel Non-Rel Subunit of NF-kappaB Confers Regulatory Specificity
Ribosomal Protein S3: A Novel Non-Rel Subunit of NF-kappaB Confers Regulatory Specificity
14:30—16:30
Workshop 2: Systems Biology of Dendritic Cells
Supported by the Society for Mathematical Biology and the NIH-funded PRiME (Program for Research on Immune Modeling and Experimentation) Initiative
Supported by the Society for Mathematical Biology and the NIH-funded PRiME (Program for Research on Immune Modeling and Experimentation) Initiative
The immune system acts across multiple scales of space and time involving complex interactions and feedback. Computational modeling provides a framework to integrate observational data collected from multiple modes of experimentation and can provide insight into immune cell function in health and disease. Computational approaches have been increasingly applied to problems in immunology, providing methods that range from the inference of transcriptional programs to the prediction of drug treatment effects on viral dynamics. This workshop will cover recent advances and potential applications of computational modeling and methods to dendritic cells.
Sonja I. Buschow,
Nijmegen Centre for Molecular Life Sciences (NCMLS) St. Radboud UMC, Netherlands
DC-ATLAS: Dissecting Signal Transduction in the Dendritic Cell with a Systems Biology Approach
DC-ATLAS: Dissecting Signal Transduction in the Dendritic Cell with a Systems Biology Approach
Laszlo Nagy,
Sanford-Burnham Medical Research Institute at Lake Nona, USA
Interrelated Nuclear Receptor Signaling Connects Lipids, the Genome and Immune Function in Dendritic Cells
Interrelated Nuclear Receptor Signaling Connects Lipids, the Genome and Immune Function in Dendritic Cells
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Uri Hershberg,
Drexel University, USA
Transcriptional Cascades in Dendritic Cells during Anti-Viral Responses
Transcriptional Cascades in Dendritic Cells during Anti-Viral Responses
Simeone Marino,
University of Michigan Medical School, USA
Roles of Dendritic Cells in the Immune Response to Bacterial and Viral Infections
Roles of Dendritic Cells in the Immune Response to Bacterial and Viral Infections
Burkhard Ludewig,
Kantonsspital St. Gallen, Switzerland
A Systems Immunological Approach to Plasmacytoid Dendritic Cell Function in Cytophatic Virus Infection
A Systems Immunological Approach to Plasmacytoid Dendritic Cell Function in Cytophatic Virus Infection
Elodie Segura,
Walter and Elizabeth Hall Institute, Australia
Novel Functional Specialization of Dendritic Cell Subsets Revealed by Plasma Membrane Comparative Proteomic Analysis
Novel Functional Specialization of Dendritic Cell Subsets Revealed by Plasma Membrane Comparative Proteomic Analysis
14:30—16:30
Workshop 3: RLH and Other Pathogen Sensors
William J. Kaiser,
Emory University School of Medicine, USA
RHIM-dependent Control of NF-kappaB and Cell Death Activation via the DNA-dependent Activator of Interferon Regulatory Factors (DAI/ZBP1/DLM-1)
RHIM-dependent Control of NF-kappaB and Cell Death Activation via the DNA-dependent Activator of Interferon Regulatory Factors (DAI/ZBP1/DLM-1)
Pingwei Li,
Texas A&M University, USA
The RIG-I Like Receptor LGP2 Recognizes the Termini of Double-Stranded RNA
The RIG-I Like Receptor LGP2 Recognizes the Termini of Double-Stranded RNA
Julien Pothlichet,
Institut Pasteur, France
A Comprehensive Study of Human RIG-I Single-Nucleotide Polymorphisms (SNPs) Identifies Two Variants with a Major Functional Impact on Antiviral Host Response
A Comprehensive Study of Human RIG-I Single-Nucleotide Polymorphisms (SNPs) Identifies Two Variants with a Major Functional Impact on Antiviral Host Response
Mehul S. Suthar,
University of Washington, USA
The RLR Signaling Pathway is Essential in Triggering an Innate Immune Response to WNV Infection
The RLR Signaling Pathway is Essential in Triggering an Innate Immune Response to WNV Infection
Szu-Ting Chen,
National Yang Ming University, Taiwan
CLEC5A, A Pattern Recognition Receptor to Flavivirus
CLEC5A, A Pattern Recognition Receptor to Flavivirus
Terry K. Means,
Massachusetts General Hospital, USA
RNAi Identifies an Important Role for Scavenger Receptors in Fungal Immunity
RNAi Identifies an Important Role for Scavenger Receptors in Fungal Immunity
Juergen M. Ruland,
Technical University of Munich, Germany
17:00—19:00
Evolution of Pattern Recognition Molecules
Meeting has ended...abstracts no longer viewable online.
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Max D. Cooper,
Emory University, USA
Evolution of LRR- Based Variable Lymphocyte Receptors
Evolution of LRR- Based Variable Lymphocyte Receptors
Jules A. Hoffmann,
Institute of Cellular and Molecular Biology, France
Drosophila Pathogen Sensors
Drosophila Pathogen Sensors
Qing Zhang,
Sanford-Burnham Medical Research Institute, USA
Short Talk: Direct Connector Genes Give Rise to Novel Topology of the Innate Immune Network in Amphioxus
Short Talk: Direct Connector Genes Give Rise to Novel Topology of the Innate Immune Network in Amphioxus
17:00—19:00
Regulation of Type I Interferon Production
Meeting has ended...abstracts no longer viewable online.
Keiko Ozato,
NICHD, National Institutes of Health, USA
Molecular Mechanism of Type I Interferon Transcription in Dendritic Cells
Molecular Mechanism of Type I Interferon Transcription in Dendritic Cells
Gunther Hartmann,
Universitätsklinikum Bonn, Germany
Ligands for RIG-I: Induction of IFN by siRNA
Ligands for RIG-I: Induction of IFN by siRNA
Elina I. Zuniga,
University of California, San Diego, USA
Short Talk: Persistent Virus Infection Inhibits Type I Interferon Production by Plasmacytoid Dendritic Cells to Facilitate Opportunistic Infections
Short Talk: Persistent Virus Infection Inhibits Type I Interferon Production by Plasmacytoid Dendritic Cells to Facilitate Opportunistic Infections
Wei Cao,
UT MD Anderson Cancer Center, USA
Short Talk: Identification of a Biological Ligand for Human Plasmacytoid Dendritic Cell Receptor ILT7
Short Talk: Identification of a Biological Ligand for Human Plasmacytoid Dendritic Cell Receptor ILT7
08:00—11:15
PRRs in Dendritic Cells and Macrophages (Joint)
Meeting has ended...abstracts no longer viewable online.
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Daniel Kastner,
National Institutes of Health, USA
Marco Colonna,
Washington University School of Medicine, USA
A Novel Signaling Pathway for Myeloid Cells Proliferation and Survival
A Novel Signaling Pathway for Myeloid Cells Proliferation and Survival
Gordon D. Brown,
University of Aberdeen, UK
Lessons form Dectin-1: Insights Into Chronic Fungal Infection
Lessons form Dectin-1: Insights Into Chronic Fungal Infection
Alan Sher,
NIAID, National Institutes of Health, USA
Th1/Th2 Polarizing Functions of Dendritic Cells in the Immune Response to Parasites
Th1/Th2 Polarizing Functions of Dendritic Cells in the Immune Response to Parasites
Christine A. Biron,
Brown University, USA
Changing Access to STATs in the Regulation of Type 1 IFN Effects on Immune Cell Subsets
Changing Access to STATs in the Regulation of Type 1 IFN Effects on Immune Cell Subsets
Stephen M. Hedrick,
University of California, San Diego, USA
Short Talk: FoxO3 Controls the Magnitude of T Cell Immune Responses by Modulating Dendritic Cell Function
Short Talk: FoxO3 Controls the Magnitude of T Cell Immune Responses by Modulating Dendritic Cell Function
Nora A. Barrett,
Brigham and Women's Hospital, USA
Short Talk: Dectin-2 Recognition of House Dust Mite Triggers Cysteinyl Leukotriene Generation by Dendritic Cells
Short Talk: Dectin-2 Recognition of House Dust Mite Triggers Cysteinyl Leukotriene Generation by Dendritic Cells
14:30—16:30
Workshop 4: PAMP Sensors and Diseases
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Daniela I. Verthelyi,
U.S. Food and Drug Administration, USA
John Vincent Forrester,
University of Aberdeen, UK
A Role for Dectin-1 in T-cell Mediated Autoimmune Inflammation
A Role for Dectin-1 in T-cell Mediated Autoimmune Inflammation
Seth L. Masters,
Walter and Eliza Hall Institute, Australia
Mutations Affecting The Interleukin-1 Receptor Antagonist (IL-1Ra) Cause A New Autoinflammatory Disease
Mutations Affecting The Interleukin-1 Receptor Antagonist (IL-1Ra) Cause A New Autoinflammatory Disease
Kathleen Azzam Smoak,
NIEHS, National Institutes of Health, USA
Myeloid Differentiation Primary Response Protein 88 Couples Reverse Cholesterol Transport to Inflammation
Myeloid Differentiation Primary Response Protein 88 Couples Reverse Cholesterol Transport to Inflammation
Christophe M. Filippi,
La Jolla Institute for Allergy and Immunology, USA
Virus Utilizes TLR2 to Enhance CD4+CD25+ Regulatory T Cells in vivo and Confer them with Protective Capacity in Autoimmune Diabetes
Virus Utilizes TLR2 to Enhance CD4+CD25+ Regulatory T Cells in vivo and Confer them with Protective Capacity in Autoimmune Diabetes
Anna-Marie Fairhurst,
Singapore Immunology Network, Singapore
Innate Mechanisms in Autoimmunity
Innate Mechanisms in Autoimmunity
Menno P. J. de Winther,
Academic Medical Center, Netherlands
Myeloid Type I Interferon Signaling Promotes Atherogenesis
Myeloid Type I Interferon Signaling Promotes Atherogenesis
Li Wen,
Yale University, USA
The Role of Gut Flora through MyD88 in Type 1 Diabetes Development in NOD Mice
The Role of Gut Flora through MyD88 in Type 1 Diabetes Development in NOD Mice
Jessica Gage,
University of Ottawa Heart Institute, Canada
Specific Loss of Toll-like Receptor 2 on Bone Marrow Derived Cells Decreases Atherosclerosis in LDL Receptor Null Mice
Specific Loss of Toll-like Receptor 2 on Bone Marrow Derived Cells Decreases Atherosclerosis in LDL Receptor Null Mice
14:30—16:30
Workshop 3: Differentiation, Trafficking and Function of DC
*
Gwendalyn J. Randolph,
Washington University, USA
Aymeric Rivollier,
Lund University, Sweden
Monocytes are Precursors of F4/80highCD11cint Macrophage-Like Cells and CD11chighF4/80int Dendritic Cells in the Mouse Colon
Monocytes are Precursors of F4/80highCD11cint Macrophage-Like Cells and CD11chighF4/80int Dendritic Cells in the Mouse Colon
Michael D. Gunn,
Duke University Medical Center, USA
Blood-derived Inflammatory Dendritic Cells in Lymph Nodes Stimulate Acute Th1 Immune Responses
Blood-derived Inflammatory Dendritic Cells in Lymph Nodes Stimulate Acute Th1 Immune Responses
Guy Shakhar,
Weizmann Institute of Science, Israel
Visualizing DC Mobilization in the Skin of Live Mice Suggests how DCs Travel Inside Lymphatics and how Their Intravasation is Regulated
Visualizing DC Mobilization in the Skin of Live Mice Suggests how DCs Travel Inside Lymphatics and how Their Intravasation is Regulated
Emma Lo Kuan,
Benaroya Research Institute, USA
DC Trafficking from Perinodal Adipose Tissues to Lymph Nodes
DC Trafficking from Perinodal Adipose Tissues to Lymph Nodes
Cherié L. Butts,
Biogen, USA
Regulation of Dendritic Cell Function by Progesterone
Regulation of Dendritic Cell Function by Progesterone
Scott B. Drutman,
New York University School of Medicine, USA
Mature Dendritic Cells Exhibit a Broad Capacity for Antigen Capture and Presentation that can be Modulated by their Distribution
Mature Dendritic Cells Exhibit a Broad Capacity for Antigen Capture and Presentation that can be Modulated by their Distribution
Marcin T. Kortylewski,
Beckman Research Institute, City of Hope, USA
Stat3 Targeting in Dendritic Cells Eliminates a Major Brake for TLR9 Agonist-Based Immunotherapy
Stat3 Targeting in Dendritic Cells Eliminates a Major Brake for TLR9 Agonist-Based Immunotherapy
Nicolas Chevrier,
Harvard University, USA
Large Non-Coding RNAs: New Players in the Toll-like Receptor Pathways
Large Non-Coding RNAs: New Players in the Toll-like Receptor Pathways
17:00—19:00
SNPs, Clinical Diseases and Pattern Recognition Molecules/Sensors
Meeting has ended...abstracts no longer viewable online.
*
Alan Sher,
NIAID, National Institutes of Health, USA
Adrian V. S. Hill,
Jenner Institute, University of Oxford, UK
Innate Immunity Polymorphisms and Susceptibility to Human Infectious Diseases
Innate Immunity Polymorphisms and Susceptibility to Human Infectious Diseases
Judy H. Cho,
Icahn School of Medicine at Mount Sinai, USA
NOD2, Innate Immunity and Human Diseases
NOD2, Innate Immunity and Human Diseases
Daniel Kastner,
National Institutes of Health, USA
Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease
Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease
17:00—18:40
Dendritic Cells in Cancer and Cancer Therapy
Meeting has ended...abstracts no longer viewable online.
*
Ralph M. Steinman,
Rockefeller University, USA
*
Sebastian Amigorena,
Institut Curie, France
Jacques F. Banchereau,
The Jackson Laboratory for Genomic Medicine, USA
Cancer Associated Dendritic Cells
Cancer Associated Dendritic Cells
Guido Kroemer,
Cordeliers Research Center, France
Immunogenic Cell Death for Optimal Anti-Cancer Chemotherapy
Immunogenic Cell Death for Optimal Anti-Cancer Chemotherapy
Carl G. Figdor,
Radboud University Medical Center, Netherlands
Human Plasmacytoid Dendritic Cells in Cancer and Cancer Therapy
Human Plasmacytoid Dendritic Cells in Cancer and Cancer Therapy
18:40—19:15
Concluding Remarks
Meeting has ended...abstracts no longer viewable online.
Ralph M. Steinman,
Rockefeller University, USA
Dendritic Cells: Translating Innate to Adaptive Immunity to Help Discover Vaccines
Dendritic Cells: Translating Innate to Adaptive Immunity to Help Discover Vaccines
*Session Chair †Invited, not yet responded.
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