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This meeting took place in 2006



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Innate Immunity (B6)


Organizer(s) Siamon Gordon and Albert S. Bendelac
February 10—15, 2006
Fairmont Banff Springs • Banff, Alberta Canada
Abstract Deadline: Oct 10, 2005
Late Abstract Deadline: Nov 2, 2005
Scholarship Deadline: Oct 10, 2005
Early Registration Deadline: Dec 9, 2005

Supported by The Director's Fund

Summary of Meeting:
The innate immune system is evolutionarily ancient, protecting the host during early stages of infectious challenge, and directing the subsequent adaptive immune response in higher organisms. The field has exploded in recent years, with insights into the role of different cell types and molecular mechanisms from recognition of pathogens to signal transduction and altered gene expression and functions. This meeting will feature some of the key investigators in the field who will present recent research on model systems, myeloid cell and natural lymphocyte receptors, TLR and other signalling pathways, and interactions with infectious agents and malignancy. The meeting will conclude with examples of how disorders of innate immunity can give rise to important diseases.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, FEBRUARY 10

15:00—19:30
Registration

Van Horne Ballroom Foyer
18:30—19:30
Refreshments

Van Horne Ballroom Foyer
19:30—20:30
Keynote Address: Innate Immune Recognition
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A
Max D. Cooper, Emory University, USA
Evolution of Immune Receptors from Innate to Adaptive Immunity


SATURDAY, FEBRUARY 11

07:00—08:00
Breakfast

Alberta/New Brunswick
08:00—11:00
Innate Recognition in Model Systems
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A
Jeffery L. Dangl, University of North Carolina at Chapel Hill, USA
Intracellular Disease Resistance Pathways in Arabidopsis

Cyril Zipfel, University of Zurich, Switzerland
Short Talk: Receptor Kinases as PAMP Receptors in Plants

Jonathan A. Hodgkin, University of Oxford, UK
Innate Immunity to Bacteria in C. elegans

Jules A. Hoffmann, Institute of Cellular and Molecular Biology, France
Receptors and Signaling Responses to Micro-Organisms in Drosophila

* Alan Ezekowitz, Abide Therapeutics, USA
Phagocytosis: From Flies to Man

09:20—09:40
Coffee Break

Van Horne Ballroom Foyer
11:00—13:00
Poster Setup

Alberta/New Brunswick
13:00—22:00
Poster Viewing

Alberta/New Brunswick
14:30—16:30
Workshop 1: Cells and Receptors

Van Horne Ballroom A
* Wendy L. Havran, The Scripps Research Institute, USA

Paul R. Crocker, University of Dundee, UK
Characterisation of Siglec-H as a Novel Endocytic Receptor of Murine Plasmacytoid Dendritic Cells

Roman Dziarski, Indiana University School of Medicine, USA
Peptidoglycan Recognition Proteins 3 and 4 are a New Class of Human Bactericidal Proteins

Min Xu, Genentech, Inc, USA
Peptidoglycan Recognition Protein-L Mediates Protection during Intestinal Epithelial Injury

Nicolas Anfossi, Innate Pharma, France
Educating Impact of Inhibitory MHC Class I Receptors on the Acquisition of Human NK Cell Function

Deborah N. Burshtyn, University of Alberta, Canada
Killer Cell Ig-like Receptor-Dependent Signaling by LILRB1

Yaqub Hanna, Whitehead Institute for Biomedical Research, USA
Novel Functions of Human NK cells Revealed by High-Throughput Proteomic and Genomic Analysis

Mustapha Zeddou†, University of Liege, Belgium
Prostanglandin E2 Induces the Expression of Functional Inhibitory CD94/NKG2A Receptors in Human CD8+ T Lymphocytes by a Camp-Dependent Protein Kinase A Type I Pathway

16:30—17:00
Coffee Available

Van Horne Ballroom Foyer
17:00—19:00
Toll-Like Receptors and their Signaling Pathways in Mammals
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A
Bruce A. Beutler, University of Texas Southwestern Medical Center, USA
TLR Responses in ENU Mutagenized Mice

Douglas Golenbock, University of Massachusetts Medical School, USA
Ligand Binding Results in Sequential Conformational Change and dimerisation of TLR9

Taro Kawai, Osaka University, Japan
Short Talk: IPS-1: An Adaptor Triggering RIG-I- and Mda5-Dependent Type I IFN Induction

* Richard Joel Ulevitch, The Scripps Research Institute, USA
The Many Faces of Innate Immunity from Infection to Malignancy

19:00—20:00
Social Hour with Lite Bites

Alberta/New Brunswick
19:30—22:00
Poster Session 1

Alberta/New Brunswick

SUNDAY, FEBRUARY 12

07:00—08:00
Breakfast

Alberta/New Brunswick
08:00—11:00
Non-Toll Recognition of Micro-Organisms
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A
Yvette van Kooyk, Vrije University Medical Center, Netherlands
C-type lectins and pathogen interactions

Gordon D. Brown, University of Aberdeen, UK
Dectin-1 and Fungal Recognition

* Siamon Gordon, Chang Gung University / University of Oxford, UK
Scavenger Receptors and Microbial Recognition

Marco Colonna, Washington University School of Medicine, USA
The Opposing Functions of TREM/DAP12 in Innate Immune Response

Jessica K. Bell, Virginia Commonwealth University, USA
Short Talk: The Structure of Toll-Like Receptor 3 Ligand Binding Domain

09:20—09:40
Coffee Break

Van Horne Ballroom Foyer
11:00—13:00
Poster Setup

Alberta/New Brunswick
13:00—22:00
Poster Viewing

Alberta/New Brunswick
14:30—16:30
Workshop 2: Signaling and Cellular Responses

Van Horne Ballroom A
* Kate A. Fitzgerald, University of Massachusetts Medical School, USA

Suzanne S. Bohlson, University of California, Irvine, USA
CD93 Cleavage Products in Inflammation and Phagocytosis

Tracie A. Seimon, Columbia University, USA
Scavenger Receptor-A Ligands Alter TLR4 Signaling to Promote Apoptosis in ER-Stressed Macrophages

Thomas A. Kufer, University of Hohenheim, Germany
Screening for Interaction Partners of the Human NACHT-LRR Proteins Nod1 and Nod2

Oystein Sandanger, Norwegian University of Science and Technology, Norway
Characterization of MD-2 Localization and Expression using a Newly Developed Monoclonal Antibody

Lee M. Shaughnessy, University of Michigan, USA
Protein Kinase C Epsilon Activation to Vacuolar Perforation by Listeria monocytogenes in Macrophages

Lynda M. Stuart, Bill & Melinda Gates Foundation, USA
Using Systems Biology to Examine the Drosophila Phagosome and Define the Basic Template of Phagocytosis

Emre E. Turer, University of Texas Southwestern, USA
The Ubiquitin-Modifying Enzyme A20 is Required for Termination of Toll-Like Receptor Responses in vivo

16:30—17:00
Coffee Available

Van Horne Ballroom Foyer
17:00—19:00
Sensing Signals within the Cell
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A
Fabio Martinon, Harvard School of Public Health, USA
NLRs Join TLRs as Innate Sensors

Zhijian 'James' Chen, University of Texas Southwestern Medical Center, USA
Ubiquitin Signaling in the NF-kappaB Pathway

* Gabriel Nuñez, University of Michigan, USA
The NOD-LRR Protein Family: Role in Immunity and Disease

19:00—20:00
Social Hour with Lite Bites

Alberta/New Brunswick
19:30—22:00
Poster Session 2

Alberta/New Brunswick

MONDAY, FEBRUARY 13

07:00—08:00
Breakfast

Alberta/New Brunswick
08:00—11:00
Cellular Responses and Host-Pathogen Interactions
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A
* Alan Aderem, Center for Infectious Disease Research, USA
A Systems Approach to Dissecting Immunity

Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
TLR's, Phagosome Maturation and Self/Non-self Discrimination

Rong-Fu Wang, Baylor College of Medicine, USA
Short Talk: Functional Control of Suppressive Function of Regulatory T Cells by Toll-Like Receptor Signaling

Michele S. Swanson, University of Michigan Medical School, USA
A NOD to Inflammatory Cell Death: Murine Macrophages Restrict Legionella Infedtion by Detecting Cytosolic Flagellin

Samuel I. Miller, University of Washington, USA
Bacterial Recognition of Innate Immunity Molecules to Promote Virulence

09:20—09:40
Coffee Break

Van Horne Ballroom Foyer
11:00—13:00
Poster Setup

Alberta/New Brunswick
13:00—22:00
Poster Viewing

Alberta/New Brunswick
14:30—16:30
Workshop 3: Innate Cell Pathogen Interactions and Adaptive Immunity

Van Horne Ballroom A
* Anne O'Garra, Francis Crick Institute, UK
Regulation of IL -10 Production in Macrophages and Dendriric Cells

Sophie Chabot, , USA
TLR2 Promotes Capture of Proteosome-Based Vaccines by Dendritic Cells in Organized Mucosal Lymphoid Tissues

Laure Gurcel, University of Geneva, Switzerland
Cholesterol Biosynthesis as a Survival Mechnism to Pore-Forming Bacterial Toxins

Adam J. Ratner, New York University School of Medicine, USA
Epithelial Innate Immune Responses to Polymicrobial Stimulation are Mediated by Entry of Peptidoglycan Fragments through Toxin Pores

Marie Charrel-Dennis, Florida State University, USA
Recognition of Group B streptococcus by Toll Like Receptors

Philip R. Taylor, Cardiff University School of Medicine, UK
Fungal Susceptibility and Defective Myeloid Cell Activation in Dectin-1-Deficient Mice

16:30—17:00
Coffee Available

Van Horne Ballroom Foyer
17:00—19:00
Regulation of Innate Immunity to Microbial Infection
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A
Wayne M. Yokoyama, Washington University School of Medicine, USA
Role of Natural Killer Cells in Innate Ant-Viral Defense

Yasmina Laouar, University of Michigan, USA
Short Talk: Effects of TGF-beta on NK Cells: Outcomes on TH1 Cell Differentiation

* Christine A. Biron, Brown University, USA
Cellular Responses to Viral Infection: DC, NK Cell and Macrophage Interactions in Shaping Innate Cytokine Production

Daniel M. Davis, Imperial College London, UK
Innate Immune Cell Synapses

19:00—20:00
Social Hour with Lite Bites

Alberta/New Brunswick
19:30—22:00
Poster Session 3

Alberta/New Brunswick

TUESDAY, FEBRUARY 14

07:00—08:00
Breakfast

Alberta/New Brunswick
08:00—11:00
Recognition Mechanisms of Innate-Like Lymphocytes
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A
Luc Teyton, The Scripps Research Institute, USA
From Bacterial Wall to the CD1 Groove: the Journey of Bacterial Lipids

Michael B. Brenner, Harvard Medical School, USA
Antigen Presentation: CD1 Style

* Albert S. Bendelac, University of Chicago, USA
Exogenous and Endogenous Glycolipid Antigens Activate NKT Cells during Microbial Infections

Adrian C. Hayday, King's College London School of Medicine, UK
Unconventional T Cells and Tumor Surveillance

09:20—09:40
Coffee Break

Van Horne Ballroom Foyer
16:30—17:00
Coffee Available

Van Horne Ballroom Foyer
17:00—19:00
Innate Control of Adaptive Effector Mechanisms
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A
David H. Raulet, University of California, Berkeley, USA
Regulation of NK Cell Recognition and Self Tolerance

Bana Jabri, University of Chicago, USA
Regulation of Tissue Effector T Cells by NKG2 Receptors ans K15

* Veronika Groh-Spies, Fred Hutchinson Cancer Research Center, USA
NKG2D-dependent Negative T Cell Modulation in Tumor Immunity

19:00—20:00
Social Hour with Lite Bites

Cascade / Conservatory
20:00—23:00
Entertainment

Cascade / Conservatory

WEDNESDAY, FEBRUARY 15

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 AI066892-01




We gratefully acknowledge additional support for this conference from:

Novartis Institutes for BioMedical Research

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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