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This meeting took place in 2006
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Determinants of Host Resistance, Susceptibility or Immunopathology to Pathogens: Integrating Knowledge from Experimental Models to Human Disease (J2)
Organizer(s) Anne O'Garra, Anne E. Goldfeld, Alan Sher and Bruce D. Walker
January 6—11, 2006
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Sep 13, 2005
Late Abstract Deadline: Oct 3, 2005
Scholarship Deadline: Sep 13, 2005
Early Registration Deadline: Nov 4, 2005
Supported by the Burroughs Wellcome Fund and The Director's Fund
Joint Meeting:
Pathogen-Host Standoff: Persistent and Latent Infection (J1)
Summary of Meeting:
The type of immune response that is elicited upon infection of a host with a pathogen is critical in determining whether the pathogen is eradicated or whether chronic infection ensues. Successful protective effector responses to intracellular pathogens such as parasites, bacteria and viruses are initiated by cells of the innate immune response which produce effector cytokines such as TNF, IL-12 or IFN-alpha. These, in turn, stimulate antigen-specific Th1 cells producing IFN-alpha and CD8+ T cytotoxic T cells (CTL). Humoral immune responses also offer protection against pathogens, however rapid mutations in the organisms and/or the lack of immunizing regimens which lead to long-term protection impede successful vaccination. Host mutations in cytokine signaling pathways and signaling pathways downstream of pattern recognition receptors on host immune cells result in profound susceptibility to a number of pathogens. Furthermore, many organisms -- such as Leishmania, Schistosoma or Mycobacteria -- inhibit protective immune responses via the induction of suppressive cytokines, whereas influenza has developed molecular mechanisms to interfere directly with signaling pathways important for the induction of the host antiviral response. Overall, major reasons why we have failed to-date in eliminating human pathogens are 1) successful strategies of immunoevasion developed by pathogens to dampen an immune response and, conversely, 2) pathogen-induced immunopathologies further complicate infections. Furthermore, the emergence and re-emergence of many infectious pathogens throughout human history, the difficulty in producing effective vaccines to protect against numerous pathogens, and the inability to intervene immunologically to abrogate many chronic infectious diseases such as HIV, malaria, TB, and schistosomiasis highlight the need for a deeper understanding of the immune response to infectious challenge. Cross-fertilization of knowledge gained from animal models of infectious disease with our understanding of human immune responses to a broad range of pathogens is critical to advance the treatment and prevention of devastating pathogens.
View Scholarships/Awards
The type of immune response that is elicited upon infection of a host with a pathogen is critical in determining whether the pathogen is eradicated or whether chronic infection ensues. Successful protective effector responses to intracellular pathogens such as parasites, bacteria and viruses are initiated by cells of the innate immune response which produce effector cytokines such as TNF, IL-12 or IFN-alpha. These, in turn, stimulate antigen-specific Th1 cells producing IFN-alpha and CD8+ T cytotoxic T cells (CTL). Humoral immune responses also offer protection against pathogens, however rapid mutations in the organisms and/or the lack of immunizing regimens which lead to long-term protection impede successful vaccination. Host mutations in cytokine signaling pathways and signaling pathways downstream of pattern recognition receptors on host immune cells result in profound susceptibility to a number of pathogens. Furthermore, many organisms -- such as Leishmania, Schistosoma or Mycobacteria -- inhibit protective immune responses via the induction of suppressive cytokines, whereas influenza has developed molecular mechanisms to interfere directly with signaling pathways important for the induction of the host antiviral response. Overall, major reasons why we have failed to-date in eliminating human pathogens are 1) successful strategies of immunoevasion developed by pathogens to dampen an immune response and, conversely, 2) pathogen-induced immunopathologies further complicate infections. Furthermore, the emergence and re-emergence of many infectious pathogens throughout human history, the difficulty in producing effective vaccines to protect against numerous pathogens, and the inability to intervene immunologically to abrogate many chronic infectious diseases such as HIV, malaria, TB, and schistosomiasis highlight the need for a deeper understanding of the immune response to infectious challenge. Cross-fertilization of knowledge gained from animal models of infectious disease with our understanding of human immune responses to a broad range of pathogens is critical to advance the treatment and prevention of devastating pathogens.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
THURSDAY, JANUARY 5
FRIDAY, JANUARY 6
SATURDAY, JANUARY 7
SUNDAY, JANUARY 8
MONDAY, JANUARY 9
TUESDAY, JANUARY 10
WEDNESDAY, JANUARY 11
Conference Program Print | View meeting in 12 hr (am/pm) time
THURSDAY, JANUARY 5
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.
Francis V. Chisari,
The Scripps Research Institute, USA
Robust Hepatitis C Virus Infection in Vitro: Coevolution of Virus and Host
Robust Hepatitis C Virus Infection in Vitro: Coevolution of Virus and Host
20:00—21:00
Keynote Address
Meeting has ended...abstracts no longer viewable online.
Antonio Lanzavecchia,
Institute for Research in Biomedicine, Switzerland
The Immune Battle Against Infectious Organisms: From Mouse Models to Human Disease
The Immune Battle Against Infectious Organisms: From Mouse Models to Human Disease
08:00—11:00
Cell-Intrinsic Responses to Pathogens
Meeting has ended...abstracts no longer viewable online.
John Hiscott,
Vaccine & Gene Therapy Institute of Florida, USA
Regulation of Antiviral Defense and Apoptosis by the IRF Transcription Factors
Regulation of Antiviral Defense and Apoptosis by the IRF Transcription Factors
J. Marie Hardwick,
Johns Hopkins University Schools of Public Health and Medicine, USA
Programmed Cell Death in Viral Pathogenesis
Programmed Cell Death in Viral Pathogenesis
*
Edward S. Mocarski,
Emory University, USA
Cell Intrinsic Responses in Cytomegalovirus Replication and Pathogenesis
Cell Intrinsic Responses in Cytomegalovirus Replication and Pathogenesis
Kathryn E. Foulds,
NIAID, National Institutes of Health, USA
Short Talk: IL-10 is Required for Optimal CD8 T Cell Memory following Listeria monocytogenes Infection
Short Talk: IL-10 is Required for Optimal CD8 T Cell Memory following Listeria monocytogenes Infection
Dorian B. McGavern,
NINDS, National Institutes of Health, USA
Short Talk: Adoptive Immunotherapy Induces Dendritic Cell Recruitment and Antigen Presentation in the CNS during the Clearance of a Persistent Viral Infection
Short Talk: Adoptive Immunotherapy Induces Dendritic Cell Recruitment and Antigen Presentation in the CNS during the Clearance of a Persistent Viral Infection
17:00—19:00
Pathogen Escape from Control
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Dan R. Littman,
HHMI/New York University School of Medicine, USA
Roles of Dendritic Cells in Intestinal Immunity and HIV Pathogenesis
Roles of Dendritic Cells in Intestinal Immunity and HIV Pathogenesis
Christopher L. Karp,
Bill & Melinda Gates Foundation, USA
Regulation of TLR Signaling and the Host Interface with Pathogens and Danger
Regulation of TLR Signaling and the Host Interface with Pathogens and Danger
*
Alan G. Barbour,
University of California, Irvine, USA
Antigenic Variation by Borrelia Species in Natural Hosts
Antigenic Variation by Borrelia Species in Natural Hosts
Chris A. Benedict,
La Jolla Institute for Allergy and Immunology, USA
Short Talk: Herpesvirus Targeting of the HVEM-BTLA Cosignaling System
Short Talk: Herpesvirus Targeting of the HVEM-BTLA Cosignaling System
08:00—11:15
Immune Mechanisms for Protection versus Progression: From Mouse Models to Human Disease
Meeting has ended...abstracts no longer viewable online.
*
Anne O'Garra,
Francis Crick Institute, UK
Development of Suppressive or Protective Immune Responses to Pathogens: Implications for Control of TB
Development of Suppressive or Protective Immune Responses to Pathogens: Implications for Control of TB
Alan Sher,
NIAID, National Institutes of Health, USA
TLR Co-Operation in Host Defense against Intracellular Pathogens
TLR Co-Operation in Host Defense against Intracellular Pathogens
Anne E. Goldfeld,
Children's Hospital Boston, Harvard Medical School, USA
TB and HIV Pathogenesis: From the Field to the Bedside
TB and HIV Pathogenesis: From the Field to the Bedside
Bruce D. Walker,
Ragon Institute of MGH, MIT and Harvard, USA
Immune Control and Immune Failure in HIV infection
Immune Control and Immune Failure in HIV infection
Andrea M. Cooper,
University of Leicester, UK
Short Talk: IL-23 is Required for Vaccine-Induced Protection Against Aerosol-Delivered Mycobacterium Tuberculosis infection
Short Talk: IL-23 is Required for Vaccine-Induced Protection Against Aerosol-Delivered Mycobacterium Tuberculosis infection
Jay K. Kolls,
Tulane School of Medicin, USA
Short Talk: IL-23/IL-17: Roles in Host Defense Against Acute Extracellular Gram Negative Bacteria and Immnuopathology in Chronic Bacterial Infection
Short Talk: IL-23/IL-17: Roles in Host Defense Against Acute Extracellular Gram Negative Bacteria and Immnuopathology in Chronic Bacterial Infection
14:30—16:30
Workshop 1: Host Susceptibility and Resistance Mechanisms in Mouse and Man
Victoria Olivia Kasprowicz,
Harvard Medical School, USA
Small Virus – Big Response: Divergent CD4+ and CD8+ T Cell Immune Responses After Acute Parvovirus B19 Infection
Small Virus – Big Response: Divergent CD4+ and CD8+ T Cell Immune Responses After Acute Parvovirus B19 Infection
*
George Kassiotis,
Francis Crick Institute, UK
Memory T Helper Cell Heterogeneity
Memory T Helper Cell Heterogeneity
Anthony A. Ryan,
Centenary Institute of Cancer Medicine & Cell Biology, Australia
Targeting Antigen Presenting Cells as a Strategy to Improve Protective Immunity Against Tuberculosis
Targeting Antigen Presenting Cells as a Strategy to Improve Protective Immunity Against Tuberculosis
Anuratha Sakthianandeswaren,
Walter and Eliza Hall Institute of Medical Research, Australia
The Wound Repair Response Controls Outcome to Murine Cutaneous Leishmaniasis
The Wound Repair Response Controls Outcome to Murine Cutaneous Leishmaniasis
Thomas J. Scriba,
University of Cape Town, South Africa
Optimized HLA Class II Tetramer Staining Allows Ultra-Sensitive Detection and Phenotyping of Antigen-Specific CD4+ T Cells
Optimized HLA Class II Tetramer Staining Allows Ultra-Sensitive Detection and Phenotyping of Antigen-Specific CD4+ T Cells
Felix Yarovinsky,
University of Rochester Medical Center, USA
Toll-Like Receptor 11 Recognition Renders Toxoplasma Profilin into an Immunodominant Antigen in the CD4+T Cell Response to the Parasite
Toll-Like Receptor 11 Recognition Renders Toxoplasma Profilin into an Immunodominant Antigen in the CD4+T Cell Response to the Parasite
Karina Yusim,
Los Alamos National Laboratory, USA
Rational HIV and Hepatitis C Vaccine Design to Optimize T Cell Responses
Rational HIV and Hepatitis C Vaccine Design to Optimize T Cell Responses
Shane Crotty,
La Jolla Institute for Allergy and Immunology, USA
SAP Deficiency Triggers CD8-Mediated Immunopathology and Hypogammaglobulinemia in a Non-Herpesvirus Chronic Infection
SAP Deficiency Triggers CD8-Mediated Immunopathology and Hypogammaglobulinemia in a Non-Herpesvirus Chronic Infection
17:00—19:00
Determinants of Chronicity in Viral Infection
Meeting has ended...abstracts no longer viewable online.
Mark B. Feinberg,
IAVI International AIDS Vaccine Initiative, USA
Host-Virus Relationships in Nonpathogenic SIV Infections
Host-Virus Relationships in Nonpathogenic SIV Infections
*
David I. Watkins,
University of Miami, USA
Defining a Protective Immune Response: In vivo Depletion of CD8 Lymphocytes in Elite SIV Controllers
Defining a Protective Immune Response: In vivo Depletion of CD8 Lymphocytes in Elite SIV Controllers
Philip J. Goulder,
University of Oxford, UK
Immune Selection Pressure, Viral Evolution and Host Evolution in HIV Infection
Immune Selection Pressure, Viral Evolution and Host Evolution in HIV Infection
Charles R.M. Bangham,
Imperial College Department of Medicine, UK
Short Talk: Immune Containment and Cell to Cell Spread of the Human Leukemia Virus HTLV-1
Short Talk: Immune Containment and Cell to Cell Spread of the Human Leukemia Virus HTLV-1
08:00—11:00
Patterns of Pathogen Growth and Behavior
Meeting has ended...abstracts no longer viewable online.
Diane E. Griffin,
Johns Hopkins Bloomberg School of Public Health, USA
Measles: Virus Clearance and Protective Immunity
Measles: Virus Clearance and Protective Immunity
Herbert (Skip) W. Virgin,
Vir Biotechnology, USA
The Host:Herpesvirus Standoff: Good News from the Front of an Ancient Battle
The Host:Herpesvirus Standoff: Good News from the Front of an Ancient Battle
*
JoAnne L. Flynn,
University of Pittsburgh School of Medicine, USA
Dynamic Immune Responses in Tuberculosis
Dynamic Immune Responses in Tuberculosis
Jennifer Philips,
Washington University School of Medicine, USA
Short Talk: Genome-Wide RNAi Screens in Drosophila Identify Host Factors Involved in Mycobacterial Infection
Short Talk: Genome-Wide RNAi Screens in Drosophila Identify Host Factors Involved in Mycobacterial Infection
Linda F. van Dyk,
University of Colorado Health Sciences Center, USA
Short Talk: Interactions of a Viral Cyclin and a Host Inhibitor in Control of gammaherpesvirus Infection
Short Talk: Interactions of a Viral Cyclin and a Host Inhibitor in Control of gammaherpesvirus Infection
17:00—19:00
Regulation of Innate and Adaptive Immunity
Meeting has ended...abstracts no longer viewable online.
E. John Wherry,
University of Pennsylvania, USA
Maintenance properties of virus specific CD8 T cells during chronic infection
Maintenance properties of virus specific CD8 T cells during chronic infection
*
Yasmine Belkaid,
NIAID, National Institutes of Health, USA
Regulatory T Cells and Parasite Persistence
Regulatory T Cells and Parasite Persistence
Christine A. Biron,
Brown University, USA
Integrating and Shaping Early Events in Immunity to Viral Infections
Integrating and Shaping Early Events in Immunity to Viral Infections
Jason A. Skinner,
University of Pennsylvania School of Medicine, USA
Short Talk: Bordetella bronchiseptica Modulates Dendritic Cell Function and Host Immunity to Establish Persistent Infection
Short Talk: Bordetella bronchiseptica Modulates Dendritic Cell Function and Host Immunity to Establish Persistent Infection
08:00—11:15
Pattern Recognition in Persistent and Latent Infection (Joint)
Meeting has ended...abstracts no longer viewable online.
Eric G. Pamer,
Memorial Sloan Kettering Cancer Center, USA
Immune Response to Aspergillus fumigatus Infection
Immune Response to Aspergillus fumigatus Infection
*
Michael B. Brenner,
Harvard Medical School, USA
Lipid Antigen Presentation by CD1 Results in Rapid T Cell Activation As Well As Adaptive Immunity
Lipid Antigen Presentation by CD1 Results in Rapid T Cell Activation As Well As Adaptive Immunity
Edward J. Pearce,
Max Planck Institute of Immunobiology and Epigenetics, Germany
Helminth Control of Dendritic Cell Function
Helminth Control of Dendritic Cell Function
Weiming Yuan,
University of Southern California, USA
Short Talk: Immune Evasion of HSV-1 by Down-Regulation of CD1d Expression
Short Talk: Immune Evasion of HSV-1 by Down-Regulation of CD1d Expression
Helle Bielefeldt-Ohmann,
Colorado State University, USA
Short Talk: Helicobacter Induced Colon Cancer in Smad3 Deficient Mice: A Synergistic Effect of Dysregulated Epithelial Proliferation and Deficient Regulation of Inflammation?
Short Talk: Helicobacter Induced Colon Cancer in Smad3 Deficient Mice: A Synergistic Effect of Dysregulated Epithelial Proliferation and Deficient Regulation of Inflammation?
17:00—19:00
Genetics of Immune Responses to Pathogens
Meeting has ended...abstracts no longer viewable online.
*
Jean-Laurent Casanova,
Rockefeller University, USA
A Genetic Dissection of Cytokine-Mediated Immunity to Infection in Humans
A Genetic Dissection of Cytokine-Mediated Immunity to Infection in Humans
Richard A. Flavell,
HHMI/Yale University School of Medicine, USA
Role of Host Innate and Adaptive Immune Response Genes in Resistance to Pathogens in Mouse Models
Role of Host Innate and Adaptive Immune Response Genes in Resistance to Pathogens in Mouse Models
Thomas R. Hawn,
University of Washington, USA
Short Talk: Polymorphisms in TLR-Pathway Genes are Associated with Signaling Deficiencies and Increased Susceptibility to Tuberculosis
Short Talk: Polymorphisms in TLR-Pathway Genes are Associated with Signaling Deficiencies and Increased Susceptibility to Tuberculosis
17:00—19:00
Challenges of the Intracellular Lifestyle
Meeting has ended...abstracts no longer viewable online.
*
Daniel A. Portnoy,
University of California, Berkeley, USA
How Listeria monocytogenes Avoids Killing its Host Cell
How Listeria monocytogenes Avoids Killing its Host Cell
Anita Sil,
University of California, San Francisco, USA
Histoplasma capsulatum Development in Pathogenesis
Histoplasma capsulatum Development in Pathogenesis
Yun Ling,
Brown University, USA
Short Talk: Rapid Elimination of Toxoplasma gondii in Primed Macrophages: The Role of IGTP and Lysosomal Fusion
Short Talk: Rapid Elimination of Toxoplasma gondii in Primed Macrophages: The Role of IGTP and Lysosomal Fusion
08:00—11:15
Pathogen Manipulation of the Host Immune Response; For Better or For Worse
Meeting has ended...abstracts no longer viewable online.
Carl F. Nathan,
Weill Cornell Medical College, USA
Host-Pathogen Relationship as Competitive Genomic Immunological Challenges of TB
Host-Pathogen Relationship as Competitive Genomic Immunological Challenges of TB
Philippe J. Sansonetti,
Institut Pasteur, France
Rupture, Invasion and Inflammatory Destruction of the Intestinal Epithelium by Shigella: The Yin and the Yang of Innate Immunity
Rupture, Invasion and Inflammatory Destruction of the Intestinal Epithelium by Shigella: The Yin and the Yang of Innate Immunity
Françoise Barré-Sinoussi,
Institut Pasteur, France
Lessons from Early Responses to Nonpathogenic SIV Infection in African Green Monkeys
Lessons from Early Responses to Nonpathogenic SIV Infection in African Green Monkeys
*
Carl F. Ware,
Sanford-Burnham Medical Research Institute, USA
Virus Modulation of the TNF Superfamily
Virus Modulation of the TNF Superfamily
Javier A. Carrero,
Washington University, USA
Short Talk: Role of Listeriolysin O in the in vivo Virulence of Listeria Monocytogenes
Short Talk: Role of Listeriolysin O in the in vivo Virulence of Listeria Monocytogenes
John E. Connolly,
Tessa Therapeutics Ltd., Singapore
Short Talk: Respiratory Syncytial Virus Subverts the Immune Response through the Induction of Tolerogenic Myeloid Dendritic Cells
Short Talk: Respiratory Syncytial Virus Subverts the Immune Response through the Induction of Tolerogenic Myeloid Dendritic Cells
14:30—16:30
Workshop 2: Shared Mechanisms of Pathogenesis in Mice and Men
*
Paul Klenerman,
University of Oxford, UK
Sara R. Klucking,
Emory University, USA
Inefficient Production of IFNa by pDCs is Involved in the Limited Immune Activation and AIDS-Resistance in Naturally SIV-Infected SMs.
Inefficient Production of IFNa by pDCs is Involved in the Limited Immune Activation and AIDS-Resistance in Naturally SIV-Infected SMs.
Alasdair J. Leslie,
Kwazulu Natal Research Institute for HIV and TB, South Africa
The Biological Relevance of Supertypes in HIV-1 Infection
The Biological Relevance of Supertypes in HIV-1 Infection
Emily J. Lyons,
Wellcome Trust Centre for Human Genetics, UK
Consanguinity and Susceptibility to Human Infectious Diseases
Consanguinity and Susceptibility to Human Infectious Diseases
Amarendra Pegu,
NIAID, National Institutes of Health, USA
Interactions between Mycobacterium Tuberculosis and the Lymphatic Endothelium
Interactions between Mycobacterium Tuberculosis and the Lymphatic Endothelium
Shahin Ranjbar,
Immune Disease Institute, USA
Tat from HIV-1 Subtype E Selectively Inhibits TNF Gene Expression via Interference with Chromatin Remodeling of the TNF Locus
Tat from HIV-1 Subtype E Selectively Inhibits TNF Gene Expression via Interference with Chromatin Remodeling of the TNF Locus
Thuong T. T. Nguyen,
Oxford University Clinical Research Unit, Vietnam
A Polymorphism in Human TLR2 is Associated with Increased Susceptibility to Tuberculous Meningitis
A Polymorphism in Human TLR2 is Associated with Increased Susceptibility to Tuberculous Meningitis
Esther Van De Vosse,
Leiden University Medical Center, Netherlands
Host Genetics of Salmonella (para-) Typhi Infection
Host Genetics of Salmonella (para-) Typhi Infection
17:00—19:00
Diverse Immune Cells Combat Pathogens
Meeting has ended...abstracts no longer viewable online.
*
Stefan H. E. Kaufmann,
Max Planck Institute for Infection Biology, Berlin, Germany
Interpretation of the Natural Host-Pathogen Crosstalk Provides Guidelines for Vaccine Design against Tuberculosis
Interpretation of the Natural Host-Pathogen Crosstalk Provides Guidelines for Vaccine Design against Tuberculosis
David L. Sacks,
NIAID, National Institutes of Health, USA
Immunology of Non-Curing Forms of Leishmaniasis in Mice and Humans
Immunology of Non-Curing Forms of Leishmaniasis in Mice and Humans
Paul Klenerman,
University of Oxford, UK
HCV immunology – Tracking T cells in viral persistence
HCV immunology – Tracking T cells in viral persistence
David G. Brooks,
Princess Margaret Cancer Center, Canada
Short Talk: Functional Re-Programming of Antiviral T Cells: Prevention of Clonal Deletion and Restoration of T Cell Activity during Persistent Viral Infection
Short Talk: Functional Re-Programming of Antiviral T Cells: Prevention of Clonal Deletion and Restoration of T Cell Activity during Persistent Viral Infection
08:00—11:00
Persistence in the Face of Adaptive
Meeting has ended...abstracts no longer viewable online.
Britta C. Urban,
University of Oxford, UK
Modulation of Dendritic Cell Funtion by Plasmodium Falciparum-Infected Erythrocytes: The Malaria-T Cell Standoff
Modulation of Dendritic Cell Funtion by Plasmodium Falciparum-Infected Erythrocytes: The Malaria-T Cell Standoff
Kevin B. Urdahl,
University of Washington, USA
Location and Function of Foxp3-Expressing T Regulatory Cells during Tuberculosis
Location and Function of Foxp3-Expressing T Regulatory Cells during Tuberculosis
*
Michael Starnbach,
Harvard Medical School, USA
Cellular Immune Control of Persistent Bacterial Infection
Cellular Immune Control of Persistent Bacterial Infection
David M. Lewinsohn,
Oregon Health & Science University, USA
Short Talk: HLA-E Restricted Human CD8+ T Cells Recognize Post-Translationally Modified HspX from Mycobacterium Tuberculosis
Short Talk: HLA-E Restricted Human CD8+ T Cells Recognize Post-Translationally Modified HspX from Mycobacterium Tuberculosis
17:00—19:00
Successful Persistence and Latency Themes
Meeting has ended...abstracts no longer viewable online.
Louis J. Picker,
Oregon Health & Science University, USA
Immunobiology of Cmv Infection in Rhesus Macaques
Immunobiology of Cmv Infection in Rhesus Macaques
Christopher M. Walker,
Nationwide Children's Hospital, USA
Protection Against Hepatitis C Virus Infection
Protection Against Hepatitis C Virus Infection
*
David Thorley-Lawson,
Tufts University School of Medicine, USA
Persistence of the Epstein-Barr Virus and the Origins of Associated Lymphomas for Real and in Virtual Reality.
Persistence of the Epstein-Barr Virus and the Origins of Associated Lymphomas for Real and in Virtual Reality.
Rajeev Mani Nepal,
Ohio State University, USA
Short Talk: DM, but not Cathepsin L, is Required to Control an Aerosol Infection with Mycobacterium tuberculosis
Short Talk: DM, but not Cathepsin L, is Required to Control an Aerosol Infection with Mycobacterium tuberculosis
08:00—11:00
Type-1 IFN: Friend or Foe
Meeting has ended...abstracts no longer viewable online.
*
Giorgio Trinchieri,
NCI, National Institutes of Health, USA
IFN-alpha in the Fight Against Infectious Diseases
IFN-alpha in the Fight Against Infectious Diseases
Malik Peiris,
University of Hong Kong, Hong Kong
SARS, Avian Influenza and Innate Immune Responses
SARS, Avian Influenza and Innate Immune Responses
Emil R. Unanue,
Washington University School of Medicine, USA
Lymphocyte Apoptosis in Infection: Molecular Basis and Biology
Lymphocyte Apoptosis in Infection: Molecular Basis and Biology
Richard Pine,
Public Health Research Institute, USA
Short Talk: Autocrin/Paracrine Responses to IFNalpha/beta Produced by Mtb Infected Macrophages
Short Talk: Autocrin/Paracrine Responses to IFNalpha/beta Produced by Mtb Infected Macrophages
Steven W. Dow,
Colorado State University, USA
Short Talk: Deleterious Role for Type I Interferons in Systemic Yersinia pestis Infections
Short Talk: Deleterious Role for Type I Interferons in Systemic Yersinia pestis Infections
14:30—16:30
Workshop 3: Immunoregulation and Immune Evasion in Infectious Diseases
Ian R. Humphreys,
Cardiff University, UK
OX40 Limits CMV Persistence in an Organ-Specific Manner that is Dependent on Distinct T Cell Subsets
OX40 Limits CMV Persistence in an Organ-Specific Manner that is Dependent on Distinct T Cell Subsets
John J. Osterholzer,
Ann Arbor VA Hospital and University of Michigan, USA
CCR2 Mediates the Recruitment of Myeloid and Plasmacytoid Dendritic Cells to the Lungs of Mice Infected with Crypotoccus neoformans: Implications for Th1/Th2 Polarization
CCR2 Mediates the Recruitment of Myeloid and Plasmacytoid Dendritic Cells to the Lungs of Mice Infected with Crypotoccus neoformans: Implications for Th1/Th2 Polarization
Michael H. Shaw,
Brown University, USA
Negative Feedback Regulation of Local Th1 Immunity by IFN-gamma Induced ICOSL-Dependent Reactivation of IL-10
Negative Feedback Regulation of Local Th1 Immunity by IFN-gamma Induced ICOSL-Dependent Reactivation of IL-10
*
Merilyn H. Hibma,
University of Otago, New Zealand
Human Papillomavirus Type 16 E6 Protein Reduces Cell Surface E-Cadherin: A Mechanism for Viral Immune Evasion
Human Papillomavirus Type 16 E6 Protein Reduces Cell Surface E-Cadherin: A Mechanism for Viral Immune Evasion
*
Jean Langhorne,
Francis Crick Institute, UK
Activation of CD4 T Cells by Different Populations of Splenic Dendritic Cells In Vivo in a Model of Malaria
Activation of CD4 T Cells by Different Populations of Splenic Dendritic Cells In Vivo in a Model of Malaria
Shabaana Khader,
Washington University School of Medicine, USA
IL-12p40 Homodimer is Required for Dendritic Cell Migration and T Cell Priming Following Mycobacterium Tuberculosis Infection of the Lung
IL-12p40 Homodimer is Required for Dendritic Cell Migration and T Cell Priming Following Mycobacterium Tuberculosis Infection of the Lung
Bo Wu,
Stanford University, USA
Measurment of FOXP3 MRNA Distiguishes Active from Latent Mtb Infections
Measurment of FOXP3 MRNA Distiguishes Active from Latent Mtb Infections
17:00—18:20
Influenza Still Plagues us After A Century – Implications for Host Responses to New and Emerging Viruses such as Severe Acute Respiratory Syndrome (SARS)
Meeting has ended...abstracts no longer viewable online.
*
Kanta Subbarao,
NIAID, National Institutes of Health, USA
Host Responses to Avian Influenza and SARS: Implications for Vaccine Development
Host Responses to Avian Influenza and SARS: Implications for Vaccine Development
Herbert (Skip) W. Virgin,
Vir Biotechnology, USA
Innate and Acquired Immunity to a Novel Norovirus in Mice
Innate and Acquired Immunity to a Novel Norovirus in Mice
18:20—19:00
Future of Research in the Immunology of Infectious Disease
Meeting has ended...abstracts no longer viewable online.
Jacques F. Banchereau,
The Jackson Laboratory for Genomic Medicine, USA
Blood Leukocyte Transcriptional Fingerprints as Novel Diagnostic and Prognostic Indicators
Blood Leukocyte Transcriptional Fingerprints as Novel Diagnostic and Prognostic Indicators
*Session Chair †Invited, not yet responded.
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