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This meeting took place in 2019



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Host and the Environment in IBD: Scientific Advances Leading to New Therapeutics (A2)


Organizer(s) Gary D. Wu, Scott Snapper, Judy H. Cho and Aida Habtezion
January 13—17, 2019
Sagebrush Inn & Suites • Taos, New Mexico USA
Discounted Abstract Deadline: Oct 4, 2018
Abstract Deadline: Oct 16, 2018
Scholarship Deadline: Oct 4, 2018
Discounted Registration Deadline: Nov 13, 2018

Sponsored by Boehringer Ingelheim Pharmaceuticals, Inc., Janssen R&D: Pharmaceutical Companies of Johnson & Johnson, Takeda Pharmaceutical Company Limited and Theravance Biopharma

Summary of Meeting:
Inflammatory bowel diseases (IBD), which afflict millions of patients, are rapidly increasing in incidence world-wide in parallel with industrialization. Pathogenesis involves both host genetic as well environmental factors, with the most currently utilized therapeutics focusing on long-term host immunosuppression. Despite tremendous advances in our understanding of IBD genetics, the mucosal immune system, and environmental factors such as the gut microbiome, currently available therapeutic modalities for IBD remain suboptimal. The overall goal of this conference is to bring together world-class investigators and clinicians to discuss the latest scientific knowledge relevant to the pathogenesis of IBD and facilitate an interactive discussion to accelerate development of new opportunities to prevent and/or treat IBD. The specific aims of this conference are to: 1) Bring together a combination of clinical and basic investigators from both academia and industry to facilitate cross-disciplinary discussions focused on IBD; 2) Identify both opportunities and gaps in current knowledge of the pathogenesis of IBD important for the development of new diagnostics and therapeutics; and 3) Create a multidisciplinary environment that will inspire both young and established investigators by highlighting currently available opportunities in IBD research. The anticipated outcome will be a better understanding of the advances and challenges in developing new therapies for patients with IBD.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, January 13 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, January 17 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, January 18 in order to fully experience the meeting.

SUNDAY, JANUARY 13

16:00—20:00
Arrival and Registration

Sagebrush Lobby & Cantina
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Sagebrush Lobby & Cantina

MONDAY, JANUARY 14

07:00—08:00
Breakfast

Sagebrush Lobby & Cantina
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Gary D. Wu, Perelman School of Medicine, University of Pennsylvania, USA

Fiona M. Powrie, University of Oxford, UK
Gut Reactions: Immune Pathways in the Intestine in Health and Disease

09:00—11:30
Clinical Considerations of IBD—What’s the Goal?
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Gary D. Wu, Perelman School of Medicine, University of Pennsylvania, USA

Gilaad Kaplan, University of Calgary, Canada
Clinical Epidemiology: The Rising Incidence of IBD Associated with Industrialization

Coffee Break

Dermot P. B. McGovern, Cedars Sinai Medical Center, USA
Using Genomics to Explain the Clinical Heterogeneity of IBD

Séverine Vermeire, KU Leuven, Belgium
Current and Future Therapeutics with Companion Diagnostics in IBD

John Y. Kao, University of Michigan, USA
Short Talk: Congenital Hypothyroidism Is a Risk Factor for Inflammatory Bowel Disease

Angela Mo, Georgia Institute of Technology, USA
Short Talk: An Expression Based Risk Score for Prediction of Disease Course in Pediatric Ulcerative Colitis

11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
14:30—16:30
Workshop 1: Host Factors in IBD

Chamisa Ballroom 1
* Scott Snapper, Children`s Hospital Boston, USA

* Aida Habtezion, Stanford School of Medicine, USA

June-Yong Lee, New York University School of Medicine, USA
Pathogenic Role of Serum Amyloid A Proteins in Th17-Mediated Chronic Inflammation

Phi Luong, Boston Children's Hospital, USA
C1ORF106/INAVA-ARNO Complexes Bridge Mucosal Barrier Function with Inflammatory Signaling

Kairui Mao, NIAID, National Institutes of Health, USA
Sequential Innate and Adaptive Immunity Establishes Non-Inflammatory Gut Commensalism and Physiologic Host Lipid Metabolism

Vu Ngo, Georgia State University, USA
IL-36 Receptor Signaling Orchestrates IL-23-Mediated Gut Barrier Repair and Defense

Samuel Rubin, Stanford University School of Medicine, USA
Mass Cytometry Reveals Systemic and Local Immune Signatures that Distinguish Inflammatory Bowel Diseases

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Advances in the Genetics of IBD
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Carl Anderson, Sanger Institute, UK

Judy H. Cho, Icahn School of Medicine at Mount Sinai, USA
Precision IBD and Population Differences in Innate Immunity

Jeffrey Barrett, Genomics plc, UK
Using Human Genetics to Give the Right IBD Patient the Right Drug

Ramnik Xavier, Massachusetts General Hospital, USA
From IBD-Associated Genotypes to Altered Cellular and Organismal Function

Olga Sazonova, 23andMe, USA
Short Talk: Polygenic Modeling Identifies Individuals whose Genetic Risk for IBD Is Comparable to Positive Family History

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Chamisa Ballroom 2
19:30—22:00
Poster Session 1

Chamisa Ballroom 2

TUESDAY, JANUARY 15

07:00—08:00
Breakfast

Sagebrush Lobby & Cantina
08:00—11:15
The Mucosal Immune System in IBD—Innate Immunity
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Aida Habtezion, Stanford School of Medicine, USA

Richard S. Blumberg, Brigham and Women's Hospital, USA
FcRn Defines Immune Responses to IgG-Containing Immune Complexes

Clara Abraham, Yale University, USA
Modulation of Innate Immune Responses by IBD-associated Genes

Coffee Break

Gérard Eberl, Institut Pasteur, France
Type 3 Innate Lymphoid Cells Facing Dietary and Microbial Perturbations

Gabriel Nuñez, University of Michigan, USA
Specific NOD2-Microbiota Interactions Drive Crohn's-Like Disease

Randy S. Longman, Weill Cornell Medical College, USA
Short Talk: Intestinal Mononuclear Phagocyte-Derived TL1A Is a Central Regulator of Group 3 Innate Lymphoid Cells in Inflammatory Bowel Disease

William McAlpine, University of Texas Southwestern, USA
Short Talk: Loss of SMCR8 or WDR41 Results in Immune Dysregulation and Colitis Susceptibility

Naresh Singh Redhu, Boston Children's Hospital, USA
Short Talk: Deletion of STAT1 Ameliorates Early-Onset Colitis in IL10R-deficient Mice

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
The Mucosal Immune System in IBD—Adaptive Immunity
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Scott Snapper, Children`s Hospital Boston, USA

Eoin McKinney, Cambridge University, UK
T-Cell Exhaustion, Co-Stimulation and Clinical Outcome in Autoimmunity and Infection

Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA
Induction of Effector and Regulatory T Cells

Aida Habtezion, Stanford School of Medicine, USA
Trafficking and Immune Response in IBD

Wei Yang, University of Alabama at Birmingham, USA
Short Talk: Protein Kinase 2 (CK2) Is Required for CD4+ T Cell Function in the Pathogenesis of Colitis

Yu Hui Kang, Boston Children's Hospital, USA
Short Talk: STAT1 Signaling Shields T Cells from NK Cell-Mediated Cytotoxicity to Enable Intestinal Inflammation

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Chamisa Ballroom 2
19:30—22:00
Poster Session 2

Chamisa Ballroom 2

WEDNESDAY, JANUARY 16

07:00—08:00
Breakfast

Sagebrush Lobby & Cantina
08:00—11:15
The Environment in IBD Pathogenesis (Microbiome)
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Andreas J. Bäumler, University of California, Davis, USA
Healthy Guts Exclude Oxygen

* June L. Round, University of Utah, USA
A Role for Fungi in IBD

Coffee Break

Andrew J.S. Macpherson, University of Bern, Switzerland
Microbial Network Disturbances in Relapsing Refractory Crohn’s Disease

David N. Cook, Seres Therapeutics, Inc., USA
A Novel Approach to Treating Active Ulcerative Colitis using Microbial Consortia

Samantha Hsieh, Washington University School of Medicine, USA
Short Talk: Diet Modulates T Cell Immune Responses by Regulating the Expression of a Dominant Antigen from a Gut Symbiont

Eric C. Martens, University of Michigan Medical School, USA
Short Talk: Combined Low Dietary Fiber and Mucus-Degrading Symbiotic Gut Bacteria Cause Lethal Colitis in IL-10 Deficient Mice

Amira Metwaly, Technical University of Munich, Germany
Short Talk: Integrative Multi-Omics Identification of Biomarker Microbial Signatures

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
14:30—16:30
Workshop 2: Environmental Factors in IBD

Chamisa Ballroom 1
* Judy H. Cho, Icahn School of Medicine at Mount Sinai, USA

* Gary D. Wu, Perelman School of Medicine, University of Pennsylvania, USA

Roberta Caruso, University of Michigan, USA
Specific Host-Microbiota Interactions Drive the Development of Crohn’s Disease-Like Colitis in Mice

Benoit Chassaing, Georgia State University, USA
Dietary Emulsifiers Directly Impact Adherent and Invasive E. coli, Promoting Intestinal Inflammation

Uri Gophna, Tel Aviv University, Israel
Prolonged Antibiotic Treatment of Pouchitis Generates Broad Microbiome-Wide Resistance to Fluoroquinolones as well as Collateral Resistance

Nobuhiko Kamada, University of Michigan, USA
Adherent-Invasive Escherichia coli Employs Diet-Derived Amino Acids to Maximize its Fitness in the Inflamed Gut

Serre-Yu Wong, Mount Sinai Hospital, USA
Host Microbe and Intra-Microbiome Interactions Leading to Small Intestinal Inflammation in Nod2-/- Mice

Sungwhan F. Oh, Brigham and Women's Hospital/Harvard Medical School, USA
Structure and Immunoprotective Functions of Gut Symbiotic Glycosphingolipids: Direct Impact of the Host Diet

Hao Tran, Georgia State University, USA
Flagellin-Elicited Adaptive Immunity Suppresses Flagellated Microbiota and Vaccinates against Chronic Inflammatory Diseases

Emilie Viennois, Georgia State University, USA
Fecal miRNAs, Mediators of the Host-Microbiota Interaction, Can Restore Intestinal Health

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Barrier Function in IBD
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Dirk Haller, Technical University of Munich, Germany

Thaddeus S. Stappenbeck, Washington University School of Medicine, USA
The Intestinal Epithelium in IBD

Lora V. Hooper, University of Texas Southwestern Medical Center, USA
Interactions among the Microbiota, the Immune System and the Circadian Clock

Andrew T. Gewirtz, Georgia State University, USA
Gut microbiota, Diet and Chronic Inflammation

Pradipta Ghosh, University of California, San Diego, USA
Short Talk: Network-Based Approaches to Improve Precision and Prediction in IBD Therapeutics

Jordi M. Lanis, University of Colorado Anschutz Medical Campus, USA
Short Talk: Contributions of Creatine Kinase to Mucosal Immune Responses in Murine Colitis

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Chamisa Ballroom 2
19:30—22:00
Poster Session 3

Chamisa Ballroom 2

THURSDAY, JANUARY 17

07:00—08:00
Breakfast

Sagebrush Lobby & Cantina
08:00—11:00
Translational Opportunities (Bench to Bedside and Back Again)
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Judy H. Cho, Icahn School of Medicine at Mount Sinai, USA

Gary D. Wu, Perelman School of Medicine, University of Pennsylvania, USA
Engineering the Gut Microbiome in IBD

Scott Snapper, Children`s Hospital Boston, USA
Identifying Novel Immune Therapeutics through Studying Rare Diseases

Coffee Break

Gregory C. Gibson, Georgia Institute of Technology, USA
Integrative Genomics in Discriminating IBD Progression

Markus F. Neurath, University Hospital Erlangen, Germany
Bridging the Gap between IBD Pathogenesis and the Development of New Therapeutics

Dominic Boardman, University of British Columbia, Canada
Short Talk: Engineering Flagellin-Specific Regulatory T Cells to Restore Intestinal Homeostasis in IBD

Ting Fu, The Salk Institute, USA
Short Talk: Nutritional Modulation of Intestinal Innate Immunity by BA-FXR Axis

11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—18:45
New Technologies and Collaborations between Industry and Academia
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Clara Abraham, Yale University, USA

Scott Plevy, Janssen, USA
Restoration of Immune and Microbial Homeostasis by a Live Bacterial Therapeutic: Investigations into Mechanisms and Development of VE202

Chas Bountra, University of Oxford, UK
Big Data in Pharma-Academic Collaborations

Elizabeth Wiellette, Draper Laboratory, USA
Short Talk: A High-Throughput Microphysiologic System to Accurately Model Human Colon and Ileum

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Chamisa Ballroom 2
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Chamisa Ballroom 2

FRIDAY, JANUARY 18

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Boehringer Ingelheim Pharmaceuticals, Inc. Janssen R&D: Pharmaceutical Companies of Johnson & Johnson
Takeda Pharmaceutical Company Limited Theravance Biopharma

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 DK118917-01

Funding for this conference was made possible (in part) by 1 R13 DK118917-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

Kenneth Rainin Foundation

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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Phone:+1 970-262-1179