Firenze Fiera - Fortezza da Basso Floorplan

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This meeting took place in 2019


Here are the related meetings in 2020:
Cancer Evolution and Combinatorial Cancer Therapies: Concepts and Challenges (L1)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Cancer Metastasis: The Role of Metabolism, Immunity and the Microenvironment (M2)


Organizer(s) Erika L. Pearce, Sarah-Maria Fendt, Russell G. Jones and Peter F. Carmeliet
March 15—19, 2019
Firenze Fiera - Fortezza da Basso • Florence, Italy
Discounted Abstract Deadline: Nov 28, 2018
Abstract Deadline: Dec 11, 2018
Scholarship Deadline: Nov 28, 2018
Discounted Registration Deadline: Jan 17, 2019

Organized in collaboration with the following organizations - Cancer Research UK and Menarini International Foundation

Sponsored by Autolus Therapeutics

Summary of Meeting:
In disease states, immune cells must compete for available resources to control tissue homeostasis or mediate protective functions. This is particularly true in cancer, where rapidly proliferating and metabolically dysregulated tumors exert metabolic pressure on cells within the tumor microenvironment. Understanding how immune and non-immune cells respond to these conditions and restrain tumor growth and metastasis is critical for developing new cancer therapies. Often cancer biologists and immunologists have little crossover, and this presents a significant barrier to furthering knowledge. This interdisciplinary conference brings together immunologists and scientists focusing on cancer to reveal novel and integrated mechanistic underpinnings that lead to cancer progression/regression and metastasis. Our goals are to: Integrate cancer biologists and immunologists who have a common interest in how cellular metabolism influences cell function; raise awareness of the metabolic intersection between tumor biology and immunology; and encourage junior researchers to actively participate at this interface. Attendees will leave the conference with a stronger understanding of how metabolism in immune cells and non-immune cells influence cell function in metastasis and the tumor microenvironment. We hope that researchers from cancer biology and immunology will, as a result of their interactions, forge new collaborations founded in their mutual appreciation that engagement of particular metabolic pathways shapes cell function and fate. Given the resurgence that metabolism has seen in recent years, we think our conference will appeal broadly to many researchers across cancer biology and immunology, many of whom are interested in investigating metabolic changes in their particular systems.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Friday, March 15 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Tuesday, March 19 with a closing plenary session from 16:00 to 18:00, followed by a social hour and entertainment. We recommend return travel on Wednesday, March 20 in order to fully experience the meeting.

FRIDAY, MARCH 15

16:00—20:00
Arrival and Registration

Fureria
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Arsenale

SATURDAY, MARCH 16

08:00—08:30
Poster Setup

Arsenale
08:30—18:00
Poster Viewing

Arsenale
08:30—09:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Basilica
* Erika L. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany

Charles Swanton, Francis Crick Institute, UK
Chromosomal Instability and Genome Plasticity in Cancer Evolution, Immune Evasion and Metastasis

09:30—12:00
Interactions via the Tumor Microenvironment
Meeting has ended...abstracts no longer viewable online.

Basilica
* Sarah-Maria Fendt, VIB Leuven, Belgium

Massimiliano Mazzone, KU Leuven – VIB, Belgium
Immunometabolism in Cancer and Other Diseases

Coffee Break

Shizhen Emily Wang, University of California, San Diego, USA
Secreted miRNAs Reprogram Metabolism in the Tumor Niche

Karen H. Vousden, Francis Crick Institute, UK
ROS Regulation and Cancer Progression

Samuel F. Bakhoum, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Chromosomal Instability Promotes Metastasis through a Cytosolic DNA Response and Modulation of the Immune Microenvironment

Li Yang, NCI, National Institutes of Health, USA
Short Talk: DNMT3B Induction at Distant Site Promotes Breast Cancer Metastasis through Epigenetic Reprogramming

12:00—13:00
Lunch

Arsenale
13:00—15:30
Poster Session 1

Arsenale
15:30—16:00
Coffee Available

Arsenale
16:00—18:00
Mitochondria and Oxidative Stress in Cancer Metastasis and Immunity
Meeting has ended...abstracts no longer viewable online.

Basilica
* Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA

Erika L. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany
Mitochondrial Integrity Regulated by FABP5 is a Cell-Intrinsic Checkpoint for Treg Suppressive Function

Marcia C. Haigis, Harvard Medical School, USA
New Functions for Metabolic Byproducts in the Tumor Microenvironment

Russell G. Jones, Van Andel Research Institute, USA
Essential Nutrients for Effector T Cell Expansion

Zachary T. Schafer, University of Notre Dame, USA
Short Talk: Resistance to PD-1 Checkpoint Inhibitors Is Associated with Defective RIPK1-Mediated Mitophagy

Alexei Vazquez, CRUK Beatson Institute, UK
Short Talk: Formate Links Glycolysis to Oxidative Phosphorylation

18:00
On Own for Dinner
No registration fees are used to fund alcohol served at this function.


SUNDAY, MARCH 17

08:30—11:45
Cancer and Immunity in the Tumor Microenvironment
Meeting has ended...abstracts no longer viewable online.

Basilica
* Georgia Hatzivassiliou, Genentech, Inc., USA

Ralph J. DeBerardinis, University of Texas Southwestern Medical Center, USA
Metabolic Enablers of Cancer Progression

Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA
Microenvironmental Determinants of Tumor Metabolism

Coffee Break

Giuseppe Matarese, Università degli Studi di Napoli Federico II, Italy
Regulatory T Cells as Suppressors of Anti-Tumor Immunity

Iannis Aifantis, New York University School of Medicine, USA
Mapping the Bone Marrow Microenvironment in Single Cell Resolution

Fabio Grassi, Institute for Research in Biomedicine, Switzerland
Short Talk: Senescence Induction by the ATP-Gated P2X7 Receptor Limits T Cell Effector Response in the Tumor Microenvironment

Paula D. Bos, Virginia Commonwealth University, USA
Short Talk: Regulatory T Cells Promote Breast Cancer Progression and Metastasis by Functional Reprogramming of Bone Marrow-Derived Cell Populations

Zachary Bacigalupa, Vanderbilt University Medical Center, USA
Short Talk: Targeting ACSS2 Inhibits HIF-2α Signaling in ccRCC and Promotes Favorable T Cell Characteristics Immune Response in ccRCC

11:45—16:00
On Own for Lunch

11:45—13:00
Poster Setup

Arsenale
13:00—22:00
Poster Viewing

Arsenale
13:30—15:30
Workshop

Basilica
* Julian J. Lum, British Columbia Cancer Agency, Canada

Ho-Young Lee, Seoul National University, South Korea
The Interplay between Slow-Cycling Chemoresistant Cancer Cells and Fibroblasts in Tumor Microenvironment Mediates Tumor Recurrence in Lung Cancer

Julianna Blagih, Francis Crick Institute, UK
Loss of p53 in Tumor Cells Promotes Immune-Tolerance through Modulation of the Innate and Adaptive Immune Responses

Medhi Wangpaichitr, Miami VA Hospital, USA
Kynurenine Metabolism in Cisplatin-Resistant Lung Cancer

Nuzhat Ahmed, Fiona Elsey Cancer Research Institute, Australia
Metabolic and Immune Regulatory Signatures in Chemoresistant Ovarian Cancer Stem Cells

David R. Soto-Pantoja, Wake Forest School of Medicine, USA
Metabolic Endpoints as Biomarkers of Immune Checkpoint Therapy Response

Chia-Ning Shen, Academia Sinica, Taiwan
Mitochondrial OXPHOS Activity Is Required for Lung Metastatic Colonization of Pancreatic Cancer

Madhusudhanan Sukumar, NCI, National Institutes of Health, USA
Mitochondrial Uncoupling Protein 2 (UCP2) Regulates T Cell Longevity and Anti-Tumor Function

Jing Fan, University of Wisconsin-Madison, USA
Two-Stage Remodeling of Mitochondrial Metabolism in Macrophages Over a Course of Immune Response

15:30—16:00
Coffee Available

Arsenale
16:00—18:00
Metastasis, Tumor Vessels and Immunity
Meeting has ended...abstracts no longer viewable online.

Basilica
* Massimiliano Mazzone, KU Leuven – VIB, Belgium

Sarah-Maria Fendt, VIB Leuven, Belgium
Cancer Metabolism during Metastasis Formation

Michael Potente, Max Planck Institute for Heart and Lung Research, Germany
Metabolic Activity and Growth State in the Vascular Endothelium

Bin-Zhi Qian, University of Edinburgh, UK
Macrophage Heterogeneity in Breast Cancer Metastasis

Sophia Y. Lunt, Michigan State University, USA
Short Talk: Sialic Acid Metabolism Is a Key Driver of Breast Cancer Metastasis

Andreas Fischer, German Cancer Research Center, Germany
Short Talk: Angiocrine Signals Promote Metastasis

18:00—19:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Arsenale
18:30—21:00
Poster Session 2

Arsenale

MONDAY, MARCH 18

08:00—08:30
Poster Setup

Arsenale
08:30—16:00
Poster Viewing

Arsenale
08:30—11:45
Therapeutic Strategies for Metabolism and Immune Modulation
Meeting has ended...abstracts no longer viewable online.

Basilica
* Giuseppe Matarese, Università degli Studi di Napoli Federico II, Italy

Katya Marjon, Agios Pharmaceuticals, USA
Therapeutics Targets in Cancer Metabolism

Tim F. Greten, NCI, National Institutes of Health, USA
Targeting the Inflammation – Cancer Axis

Coffee Break

Georgia Hatzivassiliou, Genentech, Inc., USA
Dissecting the Impact of NRF2 Activation on Lung Adenocarcinoma Biology, Immune Contexture and Patient Outcomes

Gabriele A.I. Bergers, University of Leuven, Belgium
Constructing Tumor Vessels to Enhance Immunity

Julian J. Lum, British Columbia Cancer Agency, Canada
Short Talk: Understanding the Metabolome of Human TIL for Cancer Immunotherapy

Fabricio Loayza-Puch, German Cancer Research Center, Germany
Short Talk: Targeting Proline Availability in Metastatic Breast Cancer

Gus Zeiner, Chimera Bioengineering, USA
Short Talk: A Metabolism-Triggered, Localized Payload Delivery System for T Cell Therapies

11:45—13:00
Lunch

Arsenale
13:00—15:30
Poster Session 3

Arsenale
15:30—16:00
Coffee Available

Arsenale
16:00—18:00
Stem Cells in Inflammation, Cancer and Metastasis
Meeting has ended...abstracts no longer viewable online.

Basilica
* Iannis Aifantis, New York University School of Medicine, USA

Elaine V. Fuchs, Rockefeller University, USA
Skin Stem Cells in Inflammation and Cancer

Mohamed Bentires-Alj, University of Basel, University Hospital Basel, Switzerland
Cancer Targeted Therapy and Tumor Heterogeneity: Act Locally, Think Globally

Robert A. Weinberg, Massachusetts Institute of Technology, USA
The EMT, Cancer and the Stem Cell State

Guy Roukens, University Medical Center Utrecht, Netherlands
Short Talk: SOX4 is Required for Regulation of Angiogenesis and Tumor Stem Cells in Breast Cancer

Binwu Tang, NCI, National Institutes of Health, USA
Short Talk: Elucidating the Role of Breast Cancer Stem Cells in Early Metastasis through Direct Visualization and Quantitation

18:00
On Own for Dinner
No registration fees are used to fund alcohol served at this function.


TUESDAY, MARCH 19

08:30—11:45
Metabolism Meets Cancer Metastasis
Meeting has ended...abstracts no longer viewable online.

Basilica
* Michael Potente, Max Planck Institute for Heart and Lung Research, Germany

M. Celeste Simon, University of Pennsylvania, USA
Metabolic Symbioses in the Tumor Micorenvironment

Sohail F. Tavazoie, Rockefeller University, USA
Innate Immune and Metabolic Regulation of Metastatic Progression

Coffee Break

Wanjun Chen, NIDCR, National Institutes of Health, USA
D-mannose in Autoimmunity and Cancer

Arkaitz Carracedo, Center for Cooperative Research in Biosciences, Spain
Signaling and Metabolic Plasticity in the Process of Prostate Cancer Metastasis

Ana Patricia Gomes, Weill Cornell Medicine, USA
Short Talk: Age-Induced Methylmalonic Acid Accumulation Promotes Cancer Progression and Metastasis Formation

Emily Jane Kay, Beatson Institute, UK
Short Talk: Pyruvate Dehydrogenase: The Key to Epigenetic Regulation of Mammary CAFs

Yulia Panina, Francis Crick Institute, UK
Short Talk: Using Mass Spectrometry Imaging to Identify Metabolic Adaptations during Metastasis of MYC-Driven Tumors

11:45—17:00
On Own for Lunch

15:30—16:00
Coffee Available

Arsenale
16:00—17:45
Commensal Interactions: Implications for Immunity and Cancer
Meeting has ended...abstracts no longer viewable online.

Basilica
* Russell G. Jones, Van Andel Research Institute, USA

Filipe J. Gomes Cabreiro, Imperial College London, UK
Host-Microbe-Drug-Nutrient Interactions- A Holistic Approach for Cancer Treatment

Jennifer Ann Wargo, University of Texas MD Anderson Cancer Center, USA
The Gut Microbiome and PD-1 Therapy in Melanoma

Nicholas Chia, Mayo Clinic, USA
Distinct Microbes, Metabolites and Ecologies Define the Microbiome in Deficient and Proficient Mismatch Repair Colorectal Cancers

17:45—18:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Basilica
18:00—19:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Arsenale
19:00—22:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Arsenale

WEDNESDAY, MARCH 20

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Autolus Therapeutics Organized in collaboration with Cancer Research UK
Menarini International Foundation
 

We gratefully acknowledge additional support from these exhibitors at this conference:

Don Whitley Scientific Limited Fluidigm UK LTD.
HypOxygen Menarini Silicon Biosystems
10x Genomics
 
Please stop by to meet these exhibitors during the conference.


We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA239615-01

Funding for this conference was made possible (in part) by 1R13CA239615-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

Agilent American Association for Cancer Research (AACR)
GeneTex, Inc. InvivoGen

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Nick Dua, Senior Director, Communications, Email: nickd@keystonesymposia.org,
Phone:+1 970-262-1179