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This meeting took place in 2007
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Nuclear Receptor Pathways to Metabolic Regulation (Z1)
Organizer(s) Mitchell A. Lazar and Richard A. Heyman
March 27—April 1, 2007
Sheraton Steamboat Resort • Steamboat Springs, Colorado USA
Abstract Deadline: Nov 27, 2006
Late Abstract Deadline: Dec 28, 2006
Scholarship Deadline: Nov 27, 2006
Early Registration Deadline: Jan 29, 2007
Supported by the Director's Fund
Joint Meeting:
Metabolic Syndrome and Cardiovascular Risk (Z2)
Summary of Meeting:
The most exciting current research on nuclear receptors and metabolism takes a systems approach, utilizing functional genomics, molecular biology, and bioinformatics to understand the role of nuclear receptors in physiology and in the pathophysiology of metabolic diseases such as obesity, diabetes ,and metabolic syndrome. The major roadblocks to this research include the biological variation and technical precision of the state-of-art-measures of RNA, protein, and gene occupation by transcription factors, and the ability to accurately relate changes in nuclear receptor ligands and abundance to phenotypic changes. The goal of this meeting is to bring together investigators working on different nuclear receptors, and the regulation of different metabolic pathways, to present the latest and most exciting paradigmatic and technical breakthroughs.
View Scholarships/Awards
The most exciting current research on nuclear receptors and metabolism takes a systems approach, utilizing functional genomics, molecular biology, and bioinformatics to understand the role of nuclear receptors in physiology and in the pathophysiology of metabolic diseases such as obesity, diabetes ,and metabolic syndrome. The major roadblocks to this research include the biological variation and technical precision of the state-of-art-measures of RNA, protein, and gene occupation by transcription factors, and the ability to accurately relate changes in nuclear receptor ligands and abundance to phenotypic changes. The goal of this meeting is to bring together investigators working on different nuclear receptors, and the regulation of different metabolic pathways, to present the latest and most exciting paradigmatic and technical breakthroughs.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
TUESDAY, MARCH 27
WEDNESDAY, MARCH 28
THURSDAY, MARCH 29
FRIDAY, MARCH 30
SATURDAY, MARCH 31
SUNDAY, APRIL 1
Conference Program Print | View meeting in 12 hr (am/pm) time
TUESDAY, MARCH 27
19:30—21:30
Keynote Session: Clinical and Epidemiological Definition of the Metabolic Syndrome (Joint)
Meeting has ended...abstracts no longer viewable online.
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Bart Staels,
Institut Pasteur de Lille, Université Lille, France
Gerald M. Reaven,
Stanford University, USA
Insulin Resistance and the Many Faces of the Metabolic Syndrome
Insulin Resistance and the Many Faces of the Metabolic Syndrome
Elizabeth G. Nabel,
Brigham & Womens Hospital, USA
Obesity, Risk Factors and CV Disease: NHLBI Perspectives
Obesity, Risk Factors and CV Disease: NHLBI Perspectives
08:00—11:00
NR and the MS I (Joint)
Meeting has ended...abstracts no longer viewable online.
Christopher K. Glass,
University of California, San Diego, USA
Nuclear Receptors, Inflammation, and metabolic syndrome
Nuclear Receptors, Inflammation, and metabolic syndrome
Ronald M. Evans,
HHMI/The Salk Institute, USA
ERR alpha & PGC-1 beta: a Gateway to INFgamma Signaling in Innate Immunity: Balancing the Fat Equation
ERR alpha & PGC-1 beta: a Gateway to INFgamma Signaling in Innate Immunity: Balancing the Fat Equation
Bruce M. Spiegelman,
Harvard Medical School, USA
Transcriptional Control of Energy Homeostasis and Metabolic Disease
Transcriptional Control of Energy Homeostasis and Metabolic Disease
Peter Tontonoz,
University of California, Los Angeles, USA
PPAR gamma as a Central Regulator of Adipocyte Differentiation and Lipid/Glucose Metabolism
PPAR gamma as a Central Regulator of Adipocyte Differentiation and Lipid/Glucose Metabolism
Philipp E. Scherer,
University of Texas Southwestern Medical Center, USA
Short Talk: Novel Role of Adiponectin in PPAR gamma-Mediated Gene Regulation
Short Talk: Novel Role of Adiponectin in PPAR gamma-Mediated Gene Regulation
17:00—19:00
NR Coregulators and Metabolism
Meeting has ended...abstracts no longer viewable online.
*
Ronald M. Evans,
HHMI/The Salk Institute, USA
Mitchell A. Lazar,
Perelman School of Medicine, University of Pennsylvania, USA
NR Corepressors and Metabolism
NR Corepressors and Metabolism
Malcolm G. Parker,
Imperial College London, UK
Regulation of Metabolic Gene Networks by the RIP140 Transcriptional Cofactor
Regulation of Metabolic Gene Networks by the RIP140 Transcriptional Cofactor
Ajay Chawla,
University of California, San Francisco, USA
PPARs, Macrophage Activation and Insulin Resistance
PPARs, Macrophage Activation and Insulin Resistance
Reuben J. Shaw,
The Salk Institute for Biological Studies, USA
Short Talk: The LKB1/AMPK Pathway Controls Key Transcriptional Programs
Short Talk: The LKB1/AMPK Pathway Controls Key Transcriptional Programs
17:00—19:00
Novel Therapeutics for the MS
Meeting has ended...abstracts no longer viewable online.
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Dawn M. Waterworth,
GlaxoSmithKline, USA
Jonathan R. Seckl,
University of Edinburgh School of Clinical Sciences & Community Health, UK
11beta-Hydroxysteroid Dehydrogenase Type 1 and teh Metabolic Syndrome
11beta-Hydroxysteroid Dehydrogenase Type 1 and teh Metabolic Syndrome
Anne-Marie Galzin,
Sanofi-Aventis Research & Development, France
The Endocannabinoid System as a Target for Managing Obesity / Cardio-Metabolic Risk Factors
The Endocannabinoid System as a Target for Managing Obesity / Cardio-Metabolic Risk Factors
Bei B. Zhang,
Pfizer Inc., USA
Targeting the Glucagon Receptor for Glycemia Control and Beyond
Targeting the Glucagon Receptor for Glycemia Control and Beyond
Shin-ichiro Imai,
Washington University School of Medicine, USA
Short Talk: Nampt/PBEF/Visfatin Regulates Insulin Secretion in Beta Cells as a Systemic NAD Biosynthetic Enzyme
Short Talk: Nampt/PBEF/Visfatin Regulates Insulin Secretion in Beta Cells as a Systemic NAD Biosynthetic Enzyme
08:00—11:00
Nuclear Receptors and Lipid Metabolism
Meeting has ended...abstracts no longer viewable online.
*
Thomas P. Burris,
Washington University School of Medicine, USA
Vincent Giguère,
McGill University, Canada
Genome-wide orchestration of cardiac energetics and functions by orphan nuclear receptors ERRalpha and gamma
Genome-wide orchestration of cardiac energetics and functions by orphan nuclear receptors ERRalpha and gamma
Richard A. Heyman,
ORIC Pharmaceuticals, USA
Targeting Metabolic Syndrome with Selective PPARgamma Agonist: Discovery and Clinical Development
Targeting Metabolic Syndrome with Selective PPARgamma Agonist: Discovery and Clinical Development
Jorge Plutzky,
Brigham and Women's Hospital, USA
PPARs and Lipases
PPARs and Lipases
Peter A. Edwards,
UCLA, USA
FXR Modulates Lipid and Glucose Metabolism
FXR Modulates Lipid and Glucose Metabolism
Laszlo Nagy,
Sanford-Burnham Medical Research Institute at Lake Nona, USA
Short Talk: PPARg Regulates Immune Cell Function by Turning on Retinoic Acid Synthesis and RAR-Dependent Gene Expression in Developing Human Dendritic Cells
Short Talk: PPARg Regulates Immune Cell Function by Turning on Retinoic Acid Synthesis and RAR-Dependent Gene Expression in Developing Human Dendritic Cells
08:00—11:15
Hepatic Steatosis: Cause or Consequence of the MS?
Meeting has ended...abstracts no longer viewable online.
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Anna Krook,
Karolinska Institutet, Sweden
Hannele Yki-Järvinen,
University of Helsinki, Finland
Clinical Relevance and Pathogenesis of Hepatic Steatosis
Clinical Relevance and Pathogenesis of Hepatic Steatosis
C. Ronald Kahn,
Joslin Diabetes Center and Harvard Medical School, USA
Independent Pathways of Insulin Action In Regulation Of Glucose and Lipid Metabolism
Independent Pathways of Insulin Action In Regulation Of Glucose and Lipid Metabolism
Jay D. Horton,
University of Texas Southwestern Medical Center, USA
SREBPs and Components of the Metabolic Syndrome
SREBPs and Components of the Metabolic Syndrome
Steven E. Shoelson,
Harvard Medical School, Joslin Diabetes Center, USA
Impact of Inflammation as a Pathogenic Mediator in the Metabolic Syndrome
Impact of Inflammation as a Pathogenic Mediator in the Metabolic Syndrome
Carl de Luca,
, USA
Short Talk: Myeloid-Derived Toll-Like Receptor 4 (TLR4) is Required for High Fat Diet Induced Hepatic Insulin Resistance
Short Talk: Myeloid-Derived Toll-Like Receptor 4 (TLR4) is Required for High Fat Diet Induced Hepatic Insulin Resistance
Kristiaan Wouters,
Maastricht University, Netherlands
Short Talk: Hyperactivation of Macrophage TNF Signaling Inhibits Steatosis
Short Talk: Hyperactivation of Macrophage TNF Signaling Inhibits Steatosis
17:00—19:00
NRs and Energy Metabolism
Meeting has ended...abstracts no longer viewable online.
Anastasia Kralli,
Johns Hopkins Medical School, USA
ERRalpha, a Regulator of Mitochondrial Biogenesis and Adaptive Metabolism
ERRalpha, a Regulator of Mitochondrial Biogenesis and Adaptive Metabolism
Keith L. Parker,
University of Texas Southwestern Medical Center, USA
Brain-Specific Inactivation of Steroidogenic Factor 1 Causes a Metabolic Syndrome and Anxiety-like Behavior
Brain-Specific Inactivation of Steroidogenic Factor 1 Causes a Metabolic Syndrome and Anxiety-like Behavior
David D. Moore,
Baylor College of Medicine, USA
SHP and Energy Metabolism, Bile Acids and Circadian Rhythm
SHP and Energy Metabolism, Bile Acids and Circadian Rhythm
Shamina M. Rangwala,
Janssen, Johnson & Johnson, USA
Short Talk: Mice Overexpressing PGC-1alpha in Muscle Display Alterations in Fuel Selection and Oxidative Capacity
Short Talk: Mice Overexpressing PGC-1alpha in Muscle Display Alterations in Fuel Selection and Oxidative Capacity
17:00—19:00
Cardiovascular Disease in the MS
Meeting has ended...abstracts no longer viewable online.
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Nikolaus Marx,
University Hospital Aachen, Germany
Daniel S. Ory,
Washington University, USA
Deficiency of an Endogenous LXR Ligand Promotes Atherosclerosis
Deficiency of an Endogenous LXR Ligand Promotes Atherosclerosis
Gwendalyn J. Randolph,
Washington University, USA
Monocyte Subpopulations: Evaluating their Roles
Monocyte Subpopulations: Evaluating their Roles
E. Dale Abel,
University of Iowa, Carver College of Medicine, USA
Myocardial Mitochondrial Dysfunction in the Metabolic Syndrome-Molecular Mechanisms
Myocardial Mitochondrial Dysfunction in the Metabolic Syndrome-Molecular Mechanisms
Martin E. Young,
University of Alabama at Birmingham, USA
Short Talk: The Intrinsic Circadian Clock within the Cardiomyocyte Directly Regulates Myocardial Gene Expression, Metabolism, and Function
Short Talk: The Intrinsic Circadian Clock within the Cardiomyocyte Directly Regulates Myocardial Gene Expression, Metabolism, and Function
08:00—11:00
NRs and Glucose Metabolism
Meeting has ended...abstracts no longer viewable online.
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Andrea L. Hevener,
University of California, Los Angeles, USA
Joyce J. Repa,
University of Texas Southwestern Medical Center, USA
Nuclear Hormone Receptors and the Endocrine Pancrease: LXRs and Glucose Metabolism
Nuclear Hormone Receptors and the Endocrine Pancrease: LXRs and Glucose Metabolism
Klaus H. Kaestner,
University of Pennsylvania School of Medicine, USA
HNF-4alpha in beta-cell proliferation and glucose homeostasis.
HNF-4alpha in beta-cell proliferation and glucose homeostasis.
Johan Auwerx,
École Polytechnique Fédérale de Lausanne, Switzerland
Co-Factors to Coordinate Energy Expenditure
Co-Factors to Coordinate Energy Expenditure
Frank J. Gonzalez,
National Institutes of Health, USA
PPARalpha Control of Hepatic Gene Expression and Carcinogenesis
PPARalpha Control of Hepatic Gene Expression and Carcinogenesis
Enrique Saez,
The Scripps Research Institute, USA
Short Talk: The Oxysterol Receptor LXR is a Glucose Sensor
Short Talk: The Oxysterol Receptor LXR is a Glucose Sensor
08:00—11:15
Energy Metabolism, Mitochondrial Function and Lipotoxicity in the MS
Meeting has ended...abstracts no longer viewable online.
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Dennis Bruemmer,
University of Kentucky, USA
Jean E. Schaffer,
Washington University School of Medicine, USA
Lipotoxicity: A Cardiovascular Risk in the Metabolic Syndrome
Lipotoxicity: A Cardiovascular Risk in the Metabolic Syndrome
Robert V. Farese Jr.,
Harvard School of Public Health, USA
Metabolic Syndrome and Triglyceride Synthesis
Metabolic Syndrome and Triglyceride Synthesis
Mary-Elizabeth Patti,
Joslin Diabetes Center, USA
PGC-1 Dependent and Independent Pathways to MS and Diabetes Risk
PGC-1 Dependent and Independent Pathways to MS and Diabetes Risk
Karen Reue,
University of California, Los Angeles, USA
The Role of Lipin Proteins in Metabolism
The Role of Lipin Proteins in Metabolism
Peter A. Crawford,
University of Minnesota, USA
Short Talk: Myocardial Physiology is Influenced by the Gut Microbiota
Short Talk: Myocardial Physiology is Influenced by the Gut Microbiota
Martin S. Obin,
JMUSDA-HNRCA, Tufts University, USA
Short Talk: Obesity-Associated Adipocyte Death: Role in Inflammation, Peripheral Insulin Resistance and Hepatic Steatosis
Short Talk: Obesity-Associated Adipocyte Death: Role in Inflammation, Peripheral Insulin Resistance and Hepatic Steatosis
17:00—19:00
NR and the MS II (Joint)
Meeting has ended...abstracts no longer viewable online.
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Sander Kersten,
Wageningen University, Netherlands
David J. Mangelsdorf,
University of Texas Southwestern Medical Center, USA
Nuclear Receptors and FGFs: The New Endocrinology of Metabolism
Nuclear Receptors and FGFs: The New Endocrinology of Metabolism
Takashi Kadowaki,
University of Tokyo, Japan
Adiponectin, PPARs, IRSs, and Metabolic Syndrome
Adiponectin, PPARs, IRSs, and Metabolic Syndrome
08:00—11:00
New Insights into NRs and Metabolism
Meeting has ended...abstracts no longer viewable online.
*
Edwin R. Sanchez,
University of Toledo College of Medicine, USA
Beatrice Desvergne,
University of Lausanne, Switzerland
PPARbeta/delta in Gut Homeostasis
PPARbeta/delta in Gut Homeostasis
Timothy M. Willson,
GlaxoSmithKline, USA
Orphan Nuclear Receptors: Drug Targets for Metabolic Diseases
Orphan Nuclear Receptors: Drug Targets for Metabolic Diseases
Holly A. Ingraham,
University of California, San Francisco, USA
Nuclear Receptors in Metabolism (in the CNS)
Nuclear Receptors in Metabolism (in the CNS)
Sheila Collins,
Vanderbilt University Medical Center, USA
Short Talk: LXRalpha Represses Uncoupling Protein-1 Gene Transcription and Mitochondriogenesis in Adipocytes.
Short Talk: LXRalpha Represses Uncoupling Protein-1 Gene Transcription and Mitochondriogenesis in Adipocytes.
08:00—11:15
Signaling Cascades in the MS
Meeting has ended...abstracts no longer viewable online.
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Matthew Watt,
University of Melbourne, Australia
Gökhan S. Hotamisligil,
Harvard School of Public Health, USA
Endoplasmic Reticulum Stress and Inflammation in Obesity and Diabetes
Endoplasmic Reticulum Stress and Inflammation in Obesity and Diabetes
D. Grahame Hardie,
University of Dundee, UK
Role of the AMPK System in the Metabolic Syndrome
Role of the AMPK System in the Metabolic Syndrome
Yannick Le Marchand-Brustel,
INSERM, France
Defects in Insulin Signaling in Metabolic Syndrome
Defects in Insulin Signaling in Metabolic Syndrome
Daniel Lindén,
AstraZeneca, Sweden
Short Talk: Opposing Effects of Adiponectin Receptor 1 and 2 on Energy Metabolism
Short Talk: Opposing Effects of Adiponectin Receptor 1 and 2 on Energy Metabolism
Giovanni Solinas,
University of California, San Diego, USA
Short Talk: JNK in Macrophages Plays a Key Role in the Development of Obesity-Induced Insulin Resistance
Short Talk: JNK in Macrophages Plays a Key Role in the Development of Obesity-Induced Insulin Resistance
17:00—19:00
Classical NRs and Metabolism
Meeting has ended...abstracts no longer viewable online.
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John D. Baxter,
University of California, San Francisco, USA
Using the Thyroid Hormone Receptor to Attack the Metabolic Syndrome
Using the Thyroid Hormone Receptor to Attack the Metabolic Syndrome
Jacques Samarut,
Centre National de la Recherche Scientifique, France
Thyroid Hormone Receptors in the Control of Fat Metabolism
Thyroid Hormone Receptors in the Control of Fat Metabolism
Antonio C. Bianco,
University of Miami Miller School of Medicine, USA
Regulation of TR Ligand Production
Regulation of TR Ligand Production
Françoise Gofflot,
, France
Short Talk: MousePat or Systematic Expression Mapping of Nuclear Receptors in the Mouse Brain
Short Talk: MousePat or Systematic Expression Mapping of Nuclear Receptors in the Mouse Brain
17:00—19:00
Dyslipidemia of the MS: The Atherogenic Triad
Meeting has ended...abstracts no longer viewable online.
*
Ira J. Goldberg,
New York University, USA
Henry N. Ginsberg,
Columbia University College of Physicians and Surgeons, USA
Regulation of VLDL Metabolism: Substrates, Hormones, and PPARgamma
Regulation of VLDL Metabolism: Substrates, Hormones, and PPARgamma
Bart Staels,
Institut Pasteur de Lille, Université Lille, France
FXR: A Target For The Metabolic Syndrome?
FXR: A Target For The Metabolic Syndrome?
Brian N. Finck,
Washington University School of Medicine, USA
Short Talk: Involvement of Lipin 1 in the Regulation of Hepatic Triglyceride Secretion
Short Talk: Involvement of Lipin 1 in the Regulation of Hepatic Triglyceride Secretion
*Session Chair †Invited, not yet responded.
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