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This meeting took place in 2010
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Cardiovascular Development and Repair (X2)
Organizer(s) Doris A. Taylor and Brian H. Annex
February 28—March 5, 2010
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Oct 28, 2009
Late Abstract Deadline: Nov 30, 2009
Scholarship Deadline: Oct 28, 2009
Early Registration Deadline: Dec 28, 2009
Sponsored by Gilead Sciences, Inc.
Joint Meeting:
Angiogenesis in Health and Disease (X1)
Summary of Meeting:
During fetal development, cardiocytes and vascular progenitors proliferate, coalesce and organize to form a nascent organ. Yet during adult mammalian life, these same cells are incapable of responding to repair injured heart. This Keystone Symposia meeting is designed: 1) to expose scientists in the field of cardiac and vascular repair to models of successful cardiac repair in lower vertebrates, 2) to discuss repair in the context of cardiac development and 3) to begin to ask what cues and targets from each may be applicable in the adult mammal. As a companion to and overlapping with an Angiogenesis meeting, it will provide meeting-goers access to both preclinical and clinical components of cardiac and vascular repair using cells, genes and small molecules.
View Scholarships/Awards
During fetal development, cardiocytes and vascular progenitors proliferate, coalesce and organize to form a nascent organ. Yet during adult mammalian life, these same cells are incapable of responding to repair injured heart. This Keystone Symposia meeting is designed: 1) to expose scientists in the field of cardiac and vascular repair to models of successful cardiac repair in lower vertebrates, 2) to discuss repair in the context of cardiac development and 3) to begin to ask what cues and targets from each may be applicable in the adult mammal. As a companion to and overlapping with an Angiogenesis meeting, it will provide meeting-goers access to both preclinical and clinical components of cardiac and vascular repair using cells, genes and small molecules.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, FEBRUARY 28
MONDAY, MARCH 1
TUESDAY, MARCH 2
WEDNESDAY, MARCH 3
THURSDAY, MARCH 4
FRIDAY, MARCH 5
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, FEBRUARY 28
19:30—20:30
Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.
*
Doris A. Taylor,
Texas Heart Institute, USA
Eric N. Olson,
University of Texas Southwestern Medical Center, USA
MicroRNA Control of Cardiovascular Development and Disease
MicroRNA Control of Cardiovascular Development and Disease
08:00—11:15
Cardiac Development as a Model for Repair
Meeting has ended...abstracts no longer viewable online.
*
Doris A. Taylor,
Texas Heart Institute, USA
Richard P. Harvey,
University of New South Wales, Victor Chang Cardiac Research Institute, Australia
The Pericyte Continuum in Heart Development and Repair
The Pericyte Continuum in Heart Development and Repair
Nadia A. Rosenthal,
The Jackson Laboratory, USA
Epicardium: The Outer Limits of Stem Cells
Epicardium: The Outer Limits of Stem Cells
Gordon M. Keller,
University Health Network, MaRS Centre, Canada
Cardiovascular Development from Human Pluripotent Stem Cells
Cardiovascular Development from Human Pluripotent Stem Cells
Santanu Chakraborty,
Cincinnati Children's Research Foundation, USA
Short Talk: Twist1 Overexpression Promotes Heart Valve Cell Proliferation and Alters Extracellular Matrix Remodeling whereas Tbx20 Overexpression Causes Abnormal Heart Valve Primordia Formation in vivo in Mice
Short Talk: Twist1 Overexpression Promotes Heart Valve Cell Proliferation and Alters Extracellular Matrix Remodeling whereas Tbx20 Overexpression Causes Abnormal Heart Valve Primordia Formation in vivo in Mice
08:00—11:00
Arterial Specification
Meeting has ended...abstracts no longer viewable online.
*
Eli Keshet,
Hebrew University, Israel
Nathan Lawson,
University of Massachusetts Medical School, USA
Exploring Endothelial Diversity in the Zebrafish
Exploring Endothelial Diversity in the Zebrafish
Brian L. Black,
University of California, San Francisco, USA
A Combinatorial Transcriptional Code for Endothelial Development
A Combinatorial Transcriptional Code for Endothelial Development
Tao P. Zhong,
Vanderbilt University, USA
Regulation of Arterial-Venous Cell Specification and Migration
Regulation of Arterial-Venous Cell Specification and Migration
Xabier Lopez Aranguren,
Katholieke Universiteit Leuven, Belgium
Short Talk: The Nuclear Orphan Receptor COUP-TFII Plays an Essential Role in Establishing and Maintaining Venous and Lymphatic Endothelial Identity by Distinct Mechanisms
Short Talk: The Nuclear Orphan Receptor COUP-TFII Plays an Essential Role in Establishing and Maintaining Venous and Lymphatic Endothelial Identity by Distinct Mechanisms
17:00—19:00
Models of Successful Cardiac Repair
Meeting has ended...abstracts no longer viewable online.
*
Nadia A. Rosenthal,
The Jackson Laboratory, USA
Eduardo Marban,
Cedars-Sinai Medical Center, USA
Cardiac Cell Therapy: From Concept to Clinical Reality
Cardiac Cell Therapy: From Concept to Clinical Reality
Walter J. Koch,
Temple University School of Medicine, USA
Using Gene Therapy to Repair the Failing Heart
Using Gene Therapy to Repair the Failing Heart
Maria Paola Santini,
Heart Science Centre, NHLI, Imperial College London, UK
Short Talk: Cells and Factors for Cardiac Regeneration: mIGF-1-Mediated Cross-Talk between the Heart and the Bone Marrow
Short Talk: Cells and Factors for Cardiac Regeneration: mIGF-1-Mediated Cross-Talk between the Heart and the Bone Marrow
17:00—19:00
Vascular Metabolomics
Meeting has ended...abstracts no longer viewable online.
Ulf P.E. Eriksson,
Karolinska Institutet, Sweden
Vascular Endothelial Growth Factor B Controls Endothelial Fatty Acid Uptake - Implications in Fatty Acid Metabolism
Vascular Endothelial Growth Factor B Controls Endothelial Fatty Acid Uptake - Implications in Fatty Acid Metabolism
Frank J. Giordano,
Yale University, USA
Role of HIFs in Metabolic Regulation
Role of HIFs in Metabolic Regulation
Stéphane E. Germain,
INSERM, France
Short Talk: Protection Against Myocardial Infarction through Preservation of Vascular Endothelial Cell Barrier Integrity and Reduction of No-Reflow by Angiopoietin-like 4
Short Talk: Protection Against Myocardial Infarction through Preservation of Vascular Endothelial Cell Barrier Integrity and Reduction of No-Reflow by Angiopoietin-like 4
08:00—11:00
Aging Cardiocytes and Matrix - Molecular Targets for Repair
Meeting has ended...abstracts no longer viewable online.
Jeffery D. Molkentin,
Cincinnati Children's Hospital Medical Center, USA
TRPC Channels Underlie Muscle Degeneration and Hypertrophy in Response to Alterations in the ECM - Sarcolemma
TRPC Channels Underlie Muscle Degeneration and Hypertrophy in Response to Alterations in the ECM - Sarcolemma
Jeffrey N. Keller,
Pennington Biomedical Research Center, USA
Aging and Diet Effects on Proteasome and Oxidative Stress in the Heart
Aging and Diet Effects on Proteasome and Oxidative Stress in the Heart
R. John Solaro,
University of Illinois at Chicago, USA
Quantitative Comparison of Sarcomeric Phosphoproteomes of Neonatal and Adult Rat Hearts
Quantitative Comparison of Sarcomeric Phosphoproteomes of Neonatal and Adult Rat Hearts
Kyoko Imanaka-Yoshida,
Mie University, Graduate School of Medicine, Japan
Tenascin-C as a Target for Regulation of Cardiac Remodeling
Tenascin-C as a Target for Regulation of Cardiac Remodeling
Arti Anushka Ramkisoensing,
Leiden University Medical Center, Netherlands
Short Talk: Embryonic and Fetal Mesenchymal Stem Cells do Undergo Cardiac Differentiation in Contrast to their Adult Counterparts: The Younger the Better
Short Talk: Embryonic and Fetal Mesenchymal Stem Cells do Undergo Cardiac Differentiation in Contrast to their Adult Counterparts: The Younger the Better
08:00—11:15
Endothelial Cell-Tissue Interactions
Meeting has ended...abstracts no longer viewable online.
*
Nathan Lawson,
University of Massachusetts Medical School, USA
Eli Keshet,
Hebrew University, Israel
On-Site Education by VEGF of Recruited Monocytes
On-Site Education by VEGF of Recruited Monocytes
Kenneth Walsh,
University of Virginia School of Medicine, USA
Paracrine Endothelium-Myocyte Interactions
Paracrine Endothelium-Myocyte Interactions
Didier Stainier,
Max Planck Institute for Heart and Lung Research, Germany
Endothelial Cell-Tissue Interactions during Zebrafish Organogenesis
Endothelial Cell-Tissue Interactions during Zebrafish Organogenesis
Maija Bry,
University of Helsinki, Finland
VEGF-B Induces VEGFR-1 and Bmx Tyrosine Kinase-Mediated Cardiac Hypertrophy and Strong Coronary Arteriogenesis in Rats
VEGF-B Induces VEGFR-1 and Bmx Tyrosine Kinase-Mediated Cardiac Hypertrophy and Strong Coronary Arteriogenesis in Rats
Christiana Ruhrberg,
University College London, UK
Macrophages Act as Cellular Chaperones for Vascular Anastomosis
Macrophages Act as Cellular Chaperones for Vascular Anastomosis
14:30—16:30
Workshop: Conversations on Deriving and Differentiating Stem Cells for Cardiac Repair
*
Doris A. Taylor,
Texas Heart Institute, USA
14:30—15:30
Deriving Stem Cells
Stefan Braam,
Leiden University Medical Center, Netherlands
Isolation and Characterization of Multipotent Human NKX2-5 Cardiovascular Progenitors
Isolation and Characterization of Multipotent Human NKX2-5 Cardiovascular Progenitors
Xuejun H. Parsons,
San Diego Regenerative Medicine Institute, USA
Deriving Cardiac Elements from Pluripotent Human Embryonic Stem Cells for Heart Reconstitution
Deriving Cardiac Elements from Pluripotent Human Embryonic Stem Cells for Heart Reconstitution
Alexander R. Pinto,
Australian Regenerative Medicine Institute, Australia
Tissue Resident CX3CR1-Positive Macrophages and Dendritic Cells in the Injured and Uninjured Heart
Tissue Resident CX3CR1-Positive Macrophages and Dendritic Cells in the Injured and Uninjured Heart
Linda W. van Laake,
University Medical Center Utrecht, Netherlands
Reporter-Based Isolation of Induced Pluripotent Stem Cell-Derived Cardiomyocytes Reveals Limited Gene Expression Variance
Reporter-Based Isolation of Induced Pluripotent Stem Cell-Derived Cardiomyocytes Reveals Limited Gene Expression Variance
15:30—16:30
Differentiating Stem/Progenitor Cells
Miriam Brodt-Ivenshitz,
Weizmann Institute of Science, Israel
BMP-Mediated Inhibition of FGF Signaling Lies at the Heart of Differentiation
BMP-Mediated Inhibition of FGF Signaling Lies at the Heart of Differentiation
Maria Grazia Perino,
National Institutes of Health, USA
Ascorbic Acid Promotes Cardiomyogenesis in Mouse Embryonic Stem Cells via Modulation of SMADs
Ascorbic Acid Promotes Cardiomyogenesis in Mouse Embryonic Stem Cells via Modulation of SMADs
Antoine J.P. Bondue,
CUB Hopital Erasme, Belgium
Deciphering the Cellular and Transcriptional Hierarchy Acting during the Earliest Step of Multipotent Cardiovascular Progenitor Specification
Deciphering the Cellular and Transcriptional Hierarchy Acting during the Earliest Step of Multipotent Cardiovascular Progenitor Specification
17:00—19:15
Cardiac Stem Cell Sources and Niches
Meeting has ended...abstracts no longer viewable online.
*
Calum A. MacRae,
Brigham & Women's Hospital, USA
Edward E. Morrisey,
University of Pennsylvania, USA
Regulation of Cardiac Progenitor Expansion and Differentiation by Wnt Signaling
Regulation of Cardiac Progenitor Expansion and Differentiation by Wnt Signaling
Claudia Zierold,
University of Minnesota, USA
LV-Derived Stem Cells: Is it a Feasible Goal from Humans?
LV-Derived Stem Cells: Is it a Feasible Goal from Humans?
Adriana Gittenberger-de Groot,
Leiden University Medical Center, Netherlands
Short Talk: From Cardiogenesis to Cardiac Regeneration. Focus on Epicardium Derived Cells
Short Talk: From Cardiogenesis to Cardiac Regeneration. Focus on Epicardium Derived Cells
Elaine L. Shelton,
Vanderbilt University, USA
Short Talk: The Omentum: A Source of Vascular Smooth Muscle Cells for Development and Repair
Short Talk: The Omentum: A Source of Vascular Smooth Muscle Cells for Development and Repair
17:00—19:00
Vascular Development and Collaterals
Meeting has ended...abstracts no longer viewable online.
Anne C. Eichmann,
Yale University School of Medicine, USA
Development of Collaterals
Development of Collaterals
James E. Faber,
University of North Carolina, Chapel Hill, USA
Development and Genetics of Collateral Formation and Remodeling
Development and Genetics of Collateral Formation and Remodeling
Eleni Tzima,
University of North Carolina, USA
A Novel Polarity Complex that Regulates Redox Signaling in Response to Fluid Stress
A Novel Polarity Complex that Regulates Redox Signaling in Response to Fluid Stress
Suk-Won Jin,
University of North Carolina Chapel Hill, USA
Short Talk: Heterogeneity of Developing Vessels: A Unique Role for BMP in Developing Veins
Short Talk: Heterogeneity of Developing Vessels: A Unique Role for BMP in Developing Veins
08:00—11:00
Cardiovascular Genetics (Joint)
Meeting has ended...abstracts no longer viewable online.
*
William C. Sessa,
Yale University School of Medicine, USA
*
Brian H. Annex,
University of Virginia, USA
Elizabeth M. McNally,
Northwestern University, USA
Dissecting Modifier Genes for Heart and Muscle Disease
Dissecting Modifier Genes for Heart and Muscle Disease
Arya Mani,
Yale University, USA
The Genetic Link between Coronary Artery Disease and Metabolic Risk Factors
The Genetic Link between Coronary Artery Disease and Metabolic Risk Factors
Calum A. MacRae,
Brigham & Women's Hospital, USA
Genetic Basis of Atrial Fibrillation
Genetic Basis of Atrial Fibrillation
Jonathan G. Seidman,
Harvard Medical School, USA
Genetic Mechanisms of Hypertrophic Cardiomyopathy
Genetic Mechanisms of Hypertrophic Cardiomyopathy
Christian Kupatt,
Technical University Munich, Germany
Short Talk: Pathophysiological Consequences of Chronic Endothelial Angiopoietin-2 Overexpression
Short Talk: Pathophysiological Consequences of Chronic Endothelial Angiopoietin-2 Overexpression
17:00—19:00
Lessons from Cardiac Hypertrophy and Autophagy
Meeting has ended...abstracts no longer viewable online.
*
Jonathan G. Seidman,
Harvard Medical School, USA
Leslie A. Leinwand,
University of Colorado Boulder, USA
Sex Differences in Cardiac Hypertrophy: Are they Relevant for Repair?
Sex Differences in Cardiac Hypertrophy: Are they Relevant for Repair?
Joseph A. Hill,
University of Texas Southwestern Medical Center, USA
Autophagy in Cardiac Plasticity and Disease
Autophagy in Cardiac Plasticity and Disease
Francis G. Spinale,
Medical University of South Carolina, USA
Regulation and Control of the Matrix in Hypertrophy/Failure: Relevance to Cell and Regenerative Repair
Regulation and Control of the Matrix in Hypertrophy/Failure: Relevance to Cell and Regenerative Repair
Yulia Anatolevna Chudinovskikh†,
Russian Cardiovascular Scientific Center, Russia
Short Talk: New Aspects of the Morphological Features and Pathogenesis of Hypertrophic Cardiomyopathy
Short Talk: New Aspects of the Morphological Features and Pathogenesis of Hypertrophic Cardiomyopathy
17:00—19:15
Micro RNAs in the Endothelium
Meeting has ended...abstracts no longer viewable online.
*
Anne C. Eichmann,
Yale University School of Medicine, USA
William C. Sessa,
Yale University School of Medicine, USA
Regulation of Vascular Function by miRNAs
Regulation of Vascular Function by miRNAs
Ralf H. Adams,
Max Planck Institute for Molecular Biomedicine, Germany
Molecular Regulation of the Angiogenic Endothelial Phenotype
Molecular Regulation of the Angiogenic Endothelial Phenotype
Jason E. Fish,
University Health Network, Canada
Short Talk: A Novel Slit/Robo/microRNA-218 Signaling Axis Regulates VEGF-Mediated Endocardial Migration and Heart Tube Formation
Short Talk: A Novel Slit/Robo/microRNA-218 Signaling Axis Regulates VEGF-Mediated Endocardial Migration and Heart Tube Formation
Amparo Acker-Palmer,
Goethe University, Germany
EphrinB2 Regulates VEGFR2 Function in Developmental and Tumour Angiogenesis
EphrinB2 Regulates VEGFR2 Function in Developmental and Tumour Angiogenesis
08:00—11:00
Mechanisms in Cardiac Repair
Meeting has ended...abstracts no longer viewable online.
*
Brian H. Annex,
University of Virginia, USA
Michael J. Galko,
University of Texas M.D. Anderson Cancer Center, USA
The Drosophila Open Circulatory System as a Source of Cells and Signals for Tissue Repair
The Drosophila Open Circulatory System as a Source of Cells and Signals for Tissue Repair
Nikolaos G. Frangogiannis,
Baylor College of Medicine, USA
The Role of the Inflammatory Response in Cardiac Repair
The Role of the Inflammatory Response in Cardiac Repair
*
Howard A. Rockman,
Duke University Medical Center, USA
Genetics versus Genes
Genetics versus Genes
Roger J. Hajjar,
Mount Sinai School of Medicine, USA
Short Talk: Myocardial Delivery of AAV1.SERCA2a in Patients with Advanced Heart Failure: A Phase I/II Clinical Trial
Short Talk: Myocardial Delivery of AAV1.SERCA2a in Patients with Advanced Heart Failure: A Phase I/II Clinical Trial
08:00—11:00
Therapeutic Interventions
Meeting has ended...abstracts no longer viewable online.
*
Frank J. Giordano,
Yale University, USA
John Martin,
University College London, UK
Gene Therapy or Stem Cell Therapy: Which is the Future for Angiogenesis
Gene Therapy or Stem Cell Therapy: Which is the Future for Angiogenesis
Ryan J. Watts,
Denali Therapeutics Inc, USA
Antibodies Targeting Vascular and Neuronal Pathways: Understanding Antibodies and the BBB
Antibodies Targeting Vascular and Neuronal Pathways: Understanding Antibodies and the BBB
Donald M. McDonald,
University of California, San Francisco, USA
Angiogenesis Inhibitors: Risk and Return
Angiogenesis Inhibitors: Risk and Return
Victor Kotelianski,
Promedior, USA
Development of RNAi Therapeutics
Development of RNAi Therapeutics
Kory J. Lavine,
Washington University School of Medicine, USA
Short Talk: Hedgehog Signaling in Coronary Development, Growth, and Disease
Short Talk: Hedgehog Signaling in Coronary Development, Growth, and Disease
17:00—19:00
The Future of Cardiac Repair
Meeting has ended...abstracts no longer viewable online.
*
Roger J. Hajjar,
Mount Sinai School of Medicine, USA
Brian H. Annex,
University of Virginia, USA
Systems Biology Consideration in Angiogenesis and Cell Therapy: Bench to Bedside
Systems Biology Consideration in Angiogenesis and Cell Therapy: Bench to Bedside
Doris A. Taylor,
Texas Heart Institute, USA
Re-Endothelialization of Decellularized Heart Reduces Vascular Thrombogenicity
Re-Endothelialization of Decellularized Heart Reduces Vascular Thrombogenicity
17:00—19:00
Phospholipid Signaling and Late-Breaking Science
Meeting has ended...abstracts no longer viewable online.
Timothy T. Hla,
Boston Children's Hospital/Harvard Medical School, USA
S1P Signaling in the Vascular System
S1P Signaling in the Vascular System
Masahiro Murakami,
Yale University School of Medicine, USA
Short Talk:
Short Talk:
John Chappell,
University of North Carolina, USA
Short Talk: A Novel Form of Vessel Sprout Guidance Requires Soluble Flt-1 (VEGFR-1)
Short Talk: A Novel Form of Vessel Sprout Guidance Requires Soluble Flt-1 (VEGFR-1)
Lydia S. Glaw,
University of Virginia, USA
Short Talk: PDGF-B Produced by Bone Marrow-Derived Cells Is Required for Normal Perivascular Coverage after Hypoxia-Induced Angiogenesis
Short Talk: PDGF-B Produced by Bone Marrow-Derived Cells Is Required for Normal Perivascular Coverage after Hypoxia-Induced Angiogenesis
*Session Chair †Invited, not yet responded.
We gratefully acknowledge support for this conference from:
We gratefully acknowledge the generous grant for this conference provided by:
We gratefully acknowledge additional support for this conference from:
|
American Heart Association's Council on Basic Cardiovascular Sciences |
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