Steamboat Grand Floorplan

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This meeting took place in 2019



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Lipidomics and Functional Metabolic Pathways in Disease (C6)


Organizer(s) Sarah Spiegel, Charles N. Serhan and Valerie B. O'Donnell
March 31—April 4, 2019
Steamboat Grand • Steamboat Springs, Colorado USA
Discounted Abstract Deadline: Dec 11, 2018
Abstract Deadline: Dec 19, 2018
Scholarship Deadline: Dec 11, 2018
Discounted Registration Deadline: Jan 30, 2019

Supported by the Directors' Fund

Summary of Meeting:
Recently, our understanding of lipid metabolism has significantly advanced, at least in part through applying state-of-the-art lipidomic mass spectrometry approaches to cellular, cohort and animal models. A large body of evidence now exists demonstrating that bioactive lipids play key roles in regulation of biological processes important for health and disease. However, lipidomics also reveals major gaps in our knowledge, highlighting the enormous numbers and functional and structural diversity of bioactive lipids, their interactions, spatial and temporal changes and the complicated systems biology of lipid metabolism. This Keystone Symposia conference covers areas of bioactive lipid research that have been particularly impacted by these new technologies, which may have the potential to transform precision medicine. The conference covers recent progress and perspectives in the study of bioactive lipid metabolic pathways, how these interconnect and are cross-regulated, and their involvement in the regulation of disease. The conference brings together outstanding senior and junior scientists with expertise in functions of bioactive lipids as well as those with a background in mass spectrometry lipidomics, structural biology and systems biology of lipids. Goals and anticipated outcomes are: 1) To summarize new approaches and state-of-the-art mass spectrometry technology. combined with informatics and statistics, in bioactive lipid research and to gain broad understanding of their limitations and potential application to precision medicine; 2) To acquire a broader understanding of how lipidomics can be integrated with proteomics/genomics and other ‘omics technologies to develop a systems-wide view of the lipidome; 3) To gain new knowledge in spatial and temporal interactions of bioactive lipids in cellular and subcellular systems, to better understand their functions in health and diseases; and 4) To present recent findings on the biological importance of newly discovered lipids and their roles in immunity and inflammation.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Sunday, March 31 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, April 4 with a closing plenary session from 17:00 to 19:30, followed by a social hour and entertainment. We recommend return travel on Friday, April 5 in order to fully experience the meeting.

SUNDAY, MARCH 31

4:00—8:00 PM
Arrival and Registration

Korbel Foyer
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Korbel Foyer

MONDAY, APRIL 1

7:00—8:00 AM
Breakfast

Spring Creek/Burgess Creek
8:00—9:00 AM
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Korbel Grand Ballroom
* Charles N. Serhan, Brigham and Women's Hospital, USA
Resolvins and Pro-Resolving Mediators in Resolution of Inflammation and Tissue Regeneration: Targeted Metabolipidomics

9:00—11:45 AM
Resolution of Inflammation, Infection & Tissue Regeneration
Meeting has ended...abstracts no longer viewable online.

Korbel Grand Ballroom
* Charles N. Serhan, Brigham and Women's Hospital, USA

Gabrielle Fredman, Albany Medical Center, USA
Dysregulation of Resolution Pathways in Atherosclerosis

Coffee Break

Emma Borgeson, University of Gothenburg, Sweden
Lipoxins in Cardiometabolic and Kidney Disease

Valerio Chiurchiù, IRCCS Santa Lucia Foundation, Italy
Resolution of Inflammation is Altered in Chronic Inflammatory Diseases: From the Periphery to the Brain

Charles R. Brown, University of Missouri, USA
Short Talk: Eicosanoid-Mediated Clearance of Apoptotic Cells Is Critical for the Resolution of Experimental Lyme Arthritis

Takehiko Yokomizo, Juntendo University School of Medicine, Japan
Short Talk: Leukotriene B4 Promotes Neovascularization and Macrophage Recruitment in Age-Related Macular Degeneration (AMD)

Patricia C. Kane, NeuroLipid Research Foundation, USA
Short Talk: The Application of Bioactive Lipids to Attenuate Epigenetic Insult, Unfolded Proteins and Ceramides in Neurological Disorders

11:45 AM—5:00 PM
On Own for Lunch

11:45 AM—1:00 PM
Poster Setup

Spring Creek/Burgess Creek
1:00—10:00 PM
Poster Viewing

Spring Creek/Burgess Creek
3:00—4:30 PM
Workshop 1: LIPID MAPS Tools and Advances in Lipidomics Techniques
The LIPID MAPS Lipidomics Gateway is a comprehensive online resource providing databases of lipid structures and lipid-associated genes or proteins, a variety of lipidomics tools, experimental data for lipids and genes along with protocols and standards, context specific cellular networks and pathways as well as guidelines, tutorials and instructional material for the research community. It features a lipid classification system which has gained worldwide acceptance and an interactive online lipid structure database, the LIPID MAPS structure database (LMSD) with over 43,000 unique curated structures making it the largest of its kind in the world. The LIPID MAPS in-silico structure database (LMISSD) of over a million computationally generated structures covers most of the commonly occurring lipid classes. The LIPID MAPS Proteome Database (LMPD) of lipid-related genes and proteins contains data for over 8,500 genes and over 12,500 proteins from 10 major research species. One can access annotations, such as genomic DNA, mRNA, protein domain, ontology and biochemical pathway information, with cross-links to external databases, relevant to each gene/protein of interest. The Lipidomics Gateway contains a comprehensive suite of online mass spectrometry search and prediction tools to provide an integrated search and reference resource for lipidomics MS researchers. A suite of structure-drawing tools has been developed and deployed which dramatically increase the efficiency of generating large and complex lipid structures, facilitate data entry into lipid-structure databases and permit "on-demand" structure generation in conjunction with a variety of mass spectrometry–based informatics resources. LIPID MAPS is currently funded by a multi-institutional grant from the Wellcome Trust, held jointly by Cardiff University, University of California, San Diego and the Babraham Institute, Cambridge. Our international team includes programmers, curators and webmaster and is led by Valerie O’Donnell, Ed Dennis, Shankar Subramaniam and Michael Wakelam.

Korbel Grand Ballroom
* Alfred H. Merrill, Jr., Georgia Institute of Technology, USA
Introduction: A Brief History of LIPID MAPS

Eoin Fahy, University of California, San Diego, USA
The LIPID MAPS Lipidomics Gateway

Paul R.S. Baker, Avanti Polar Lipids, USA
The Essential Union Between Standards and Methodology for Quantitative Lipidomics

4:30—5:00 PM
Coffee Available

Korbel Foyer
5:00—7:00 PM
Lipidomics/Metabolomics – Global Profiling vs. Targeted Analysis
Meeting has ended...abstracts no longer viewable online.

Korbel Grand Ballroom
Craig E. Wheelock, Karolinska Institutet, Sweden
Lipid Mediator Metabolic Profiling: Sub-Phenotyping of Respiratory Disease

Markus R. Wenk, National University of Singapore, Singapore
Translation of Lipidomic Technologies towards Quantification of Blood Lipids

* Edward A. Dennis, University of California, San Diego, USA
Lipidomic Profiling in Nonalcoholic Steatohepatitis

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Spring Creek/Burgess Creek
7:30—10:00 PM
Poster Session 1

Spring Creek/Burgess Creek

TUESDAY, APRIL 2

7:00—8:00 AM
Breakfast

Spring Creek/Burgess Creek
8:00—9:00 AM
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Korbel Grand Ballroom
* Jesper Z. Haeggström, Karolinska Institute, Sweden

Lina M. Obeid, Stony Brook Medicine, USA
Sphingolipid Metabolic Pathways Regulate Cancer Metabolism

9:00 AM—12:00 PM
Novel Approaches to Lipid Metabolism
Meeting has ended...abstracts no longer viewable online.

Korbel Grand Ballroom
* Jesper Z. Haeggström, Karolinska Institute, Sweden
Deciphering Molecular Mechanisms of Enzymes in the 5-Lipoxygenase Pathway

Coffee Break

Steffany A.L. Bennett, University of Ottawa, Canada
The Lipogenetics of Dementia: Lipidomic Pathways Differentially Disrupted in Alzheimer’s Disease, Parkinson’s Disease with Dementia and Dementia with Lewy Bodies.

Antonio J. Vidal-Puig, University of Cambridge, UK
Molecular Mechanisms of Energy Balance

Junken Aoki, Tohoku University, Japan
Short Talk: A Versatile Method to Determine the Positional Specificity of Lysophospholipid Acyltransferases (LPLATs) and its Application to Identification of an sn-1 LPLAT

Joseph P. Dewulf, de Duve Institute, UCLouvain, Belgium
Short Talk: ECHDC1 Prevents the Formation of Branched Chain Fatty Acids

Nicholas Vincent DiPatrizio, University of California, Riverside, School of Medicine, USA
Short Talk: Endocannabinoids in the Gut: Lipid-Derived Mediators of Gut-Brain Signaling

Jessica M. Ellis, East Carolina University, USA
Short Talk: Acyl-CoA Synthetase 6-Mediates Docosahexaenoic Acid (DHA) Enrichment in Brain and Testis

12:00—1:00 PM
Workshop 2: The Lipidomics Standards Initiative

Korbel Grand Ballroom
* Gerhard Liebisch, University of Regensburg, Germany

* Kim Ekroos, Lipidomics Consulting Ltd., Finland

12:00—5:00 PM
On Own for Lunch

12:00—1:00 PM
Poster Setup

Spring Creek/Burgess Creek
1:00—10:00 PM
Poster Viewing

Spring Creek/Burgess Creek
4:30—5:00 PM
Coffee Available

Korbel Foyer
5:00—7:15 PM
Systems Biology of Lipids/’Omics
Meeting has ended...abstracts no longer viewable online.

Korbel Grand Ballroom
* Peter Ghazal, Cardiff University, UK
The ‘Molecular Wires’ that Link the Immune System to Cholesterol Metabolism

Manuel Mayr, King's College, University of London, UK
The Future of Lipidomics: A Multi-Omics Approach to Cardiovascular Disease Risk

Gary Siuzdak, The Scripps Research Institute, USA
Activity Metabolomics and Discovering Metabolites that Alter Physiology

Stephanie M. Cologna, University of Illinois at Chicago, USA
Short Talk: Integrating Proteomics and Lipidomics Reveals Converging Pathway Alterations in Niemann-Pick Disease Type C

Elena Lian, Colorado State University, USA
Short Talk: The Paradox of Arachidonic Acid: Can a Proinflammatory Precursor Act as a Pro-Viral Molecule to Support Flavivirus Infection?

Erin Nanette Shepheard McGowan, University of Melbourne, Australia
Short Talk: Macrophage Fatty Acid Desaturase 1 (FADS1) Is Important for the Survival of the Intracellular Parasite Leishmania Mexicana

7:15—8:15 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Spring Creek/Burgess Creek
7:30—10:00 PM
Poster Session 2

Spring Creek/Burgess Creek

WEDNESDAY, APRIL 3

7:00—8:00 AM
Breakfast

Spring Creek/Burgess Creek
8:00—11:00 AM
Lipidomics and Metabolic Syndrome
Meeting has ended...abstracts no longer viewable online.

Korbel Grand Ballroom
* Alfred H. Merrill, Jr., Georgia Institute of Technology, USA

Claudio Villanueva, University of Utah School of Medicine, USA
Global Analysis of Plasma Lipids and Adaptive Thermogenesis

Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Intracellular Lipid Metabolism Impairs β Cell Compensation during Diet-induced Obesity

Coffee Break

Morris J. Birnbaum, Pfizer Inc., USA
Pharma and Academia Cross-Talk and the Metabolic Syndrome

L. Ashley Cowart, Virginia Commonwealth University, USA
Short Talk: Sphingosine Kinase 1 Regulates Sexual Dimorphism in Non-Alcoholic Fatty Liver Disease via Estrogen-Dependent Suppression of Fibrosis

Cory P. Johnson, University of Maine, USA
Short Talk: Sending Signals: Adipose Sensory Nerves May Communicate with the Brain via Lipid Metabolites

Anna Alexanova, Tampere University, Finland
Short Talk: Modeling Lipid Metabolism of Coronary Artery Disease Patients with Induced Pluripotent Stem Cell-Derived Hepatocytes

Habtamu B. Beyene, Monash University, Australia
Short Talk: High-Throughput Plasma Lipidomic Profiling Identifies Differential Association of Lipid Signatures with Insulin Resistance in Men versus Women

11:00 AM—5:00 PM
On Own for Lunch

11:00 AM—1:00 PM
Poster Setup

Spring Creek/Burgess Creek
1:00—10:00 PM
Poster Viewing

Spring Creek/Burgess Creek
4:30—5:00 PM
Coffee Available

Korbel Foyer
5:00—7:00 PM
Cancer Lipidomics
Meeting has ended...abstracts no longer viewable online.

Korbel Grand Ballroom
* Sarah Spiegel, Virginia Commonwealth University, USA

Michael J.O. Wakelam, Babraham Institute, UK
Lipidomic Analysis of Cancer Identifies Potential Therapeutic Targets

Tim F. Greten, NCI, National Institutes of Health, USA
Mechanisms of Immune Escape in Liver Cancer

Yusuf A. Hannun, Stony Brook Cancer Center, USA
Neutral Ceramidase in Colon Cancer

Lipin Kao, East Carolina University, USA
Short Talk: Chemotherapy Selection Pressure Elicits Marked Alterations of Sphingolipid Composition in Acute Myelogenous Leukemia Cells

Justin M. Snider, Stony Brook University, USA
Short Talk: Probing Sphingolipid Flux in Response to Chemotherapeutics

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Spring Creek/Burgess Creek
7:30—10:00 PM
Poster Session 3

Spring Creek/Burgess Creek

THURSDAY, APRIL 4

7:00—8:00 AM
Breakfast

Spring Creek/Burgess Creek
8:00—11:15 AM
Lipid Signaling in Inflammation
Meeting has ended...abstracts no longer viewable online.

Korbel Grand Ballroom
* Valerie B. O'Donnell, Cardiff University, UK
Journal of Lipid Research Lectureship: Dysregulation of the Lysophospholipid/Autotaxin Axis Defines the Cardiovascular Risk SNP rs10757274 on Chromosome 9p21

Diane K. Jorkasky, Complexa Inc., USA
From the Fires of Inflammation to a Drug that Quenches the Flames: The Clinical Development of the Nitro Fatty Acid, CXA-10

Coffee Break

Marcus Conrad, Helmholtz Zentrum München, Germany
Oxidized Phospholipids in Ferroptosis and Neurodegeneration

Gerhard Krönke, Universitätsklinikum Erlangen, Germany
Lipid Oxidation as Regulative Element during Immune Tolerance and Hemostasis

John-Demian Sauer, University of Wisconsin-Madison, USA
Short Talk: Cyclooxygenase-2 Dependent Prostaglandin E2 Signaling through the EP3 Receptor Is Required for Cell-Mediated Immunity to Listeria Monocytogenes

Emily Bowman, Ohio State University, USA
Short Talk: Lipidome Abnormalities May Contribute to Altered Macrophage Phenotype in HIV Infection

Kirsten Dee Krieger, Colorado State University, USA
Short Talk: Phosphatidylcholine: A Membrane Brick or Key to Replication of Dengue Viruses?

11:15 AM—5:00 PM
On Own for Lunch

4:30—5:00 PM
Coffee Available

Korbel Foyer
5:00—7:15 PM
Lipid Recognition by the Adaptive Immune System
Meeting has ended...abstracts no longer viewable online.

Korbel Grand Ballroom
* Jamie Rossjohn, Monash University, Australia
How T Cells Sense Lipids

Graham S. Ogg, University of Oxford, UK
Lipids and Allergic Skin Disease

Chyung-Ru Wang, Northwestern University Feinberg School of Medicine, USA
Impact of Hyperlipidemia on CD1-Restricted Lipid Antigen-Specific T Cells

Mauro Corrado, Max Planck Institute of Immunology and Epigenetics, Germany
Short Talk: Cardiolipin Controls CD8+ Memory T Cell Metabolism and Function

Nicole Lane Starr, University of Wisconsin-Madison, USA
Short Talk: Lipidomic Analysis of Nasal Lavage Fluid from Healthy Subjects following Experimental Rhinovirus Inoculation

Julia Esser-von Bieren, Technical University and Helmholtz Centre Munich, Germany
Short Talk: Remodeling of Myeloid Arachidonic Acid Metabolism Imparts Helminth-Driven Control of Type 2 Inflammation

7:15—7:30 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Korbel Grand Ballroom
7:30—8:30 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Spring Creek/Burgess Creek
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Spring Creek/Burgess Creek

FRIDAY, APRIL 5

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13DK120257-01

Funding for this conference was made possible (in part) by 1R13DK120257-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

Avanti Polar Lipids, Inc. Cayman Chemical Company
Journal of Lipid Research Larodan AB
Lipotype GmbH
 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Complexa Inc.


Pfizer Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Nick Dua, Senior Director, Communications, Email: nickd@keystonesymposia.org,
Phone:+1 970-262-1179